Retrovirus lymphomagenesis: relationship of normal immune receptors to malignant cell proliferation.
Retrovirus lymphomagenesis: relationship of normal immune receptors to malignant cell proliferation.
复制标题
逆转录病毒淋巴瘤发生：正常免疫受体与恶性细胞增殖的关系。
DOI：
10.1007/978-3-642-68369-5_8
复制
发表时间：
1982
影响因子：
--
通讯作者：
M. McGrath
中科院分区：
文献类型：
--
作者：
I. Weissman;M. McGrath
在我们看来，肿瘤发生的中心损害是恶性细胞持续的、明显的不受控制的增殖，超出了正常细胞的调节数量。因此，一般而言，癌细胞的特性与特定组织或细胞类型的增殖干细胞的特性最为相似。因此，在这一观点中，恶性细胞与正常细胞在种类上没有区别，但主要是在它们的增殖室的大小上。鉴于这一观点，假设恶性肿瘤细胞利用正常的有丝分裂途径进行持续增殖是合乎逻辑的，如果想要了解恶性是如何在该细胞类型中控制的，就必须研究特定类型的细胞控制其增殖的方法。
In our view the central lesion in oncogenesis is the sustained, apparently uncontrolled proliferation of malignant cells beyond the regulated number of their normal counterparts. In general, therefore, the properties of cancer cells are most similar to those of the proliferating stem cells of that particular tissue or cell type. Thus in this view malignant cells do not differ in kind from normal cells, but mainly in the size of their proliferative compartments. Given this point of view, it is logical to assume that malignant cells utilize normal mitogenic pathways for their sustained proliferation and that one must look to means by which a particular class of cells controls its proliferation if one wishes to understand how malignancy is controlled in that cell type.
Lyt 抗体对 T 细胞功能的影响：抗 Lyt-1 增强，而不是抗 Lyt-2 抑制。
DOI：
10.1073/pnas.78.2.1148
发表时间：
1981
影响因子：
11.1
作者：
Hollander,N;Pillemer,E;Weissman,IL
通讯作者：
Weissman,IL