Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma.
Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma.
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DOI：
10.3389/fimmu.2018.00708
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发表时间：
2018
影响因子：
7.3
通讯作者：
Heinz C
中科院分区：
文献类型：
--
作者：
Bauer D;Kasper M;Walscheid K;Koch JM;Müther PS;Kirchhof B;Heiligenhaus A;Heinz C
幼年特发性关节炎患者常发生慢性前葡萄膜炎（JIAU）。JIAU患者具有特别高的风险发展为继发性青光眼时，炎症活动已经实现。通过使用多重珠分析，我们评估了临床非活动性JIAU伴继发性青光眼（JIAUwG）或不伴继发性青光眼（JIAUwo G）患者或老年性白内障患者（作为对照）的房水（AH）中促炎和抗炎细胞因子、趋化因子或金属蛋白酶的水平。手术前的激光闪光光度分析显示JIAUwG和JIAUwoG之间无显著差异。与对照组相比，临床非活动性JIAUwG或JIAUwo G患者AH中的白细胞介素-8、基质金属蛋白酶-2、-3、-9、血清淀粉样蛋白A（SAA）、转化生长因子β-1、-2、-3（TGFβ-1、-2、-3）和肿瘤坏死因子-α水平显著升高。JIAwoG患者血清SAA水平显著高于JIAwG患者（P < 0.0116）。JIAUwG组TGFβ-2水平高于JIAUwG组（P < 0.0009）。这些分子可能有助于JIAU患者青光眼的临床发展。
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls. Laser-flare photometry analysis prior to surgery showed no significant differences between JIAUwG or JIAUwoG. Compared with the control group, levels of interleukin-8, matrix metalloproteinase-2, -3, -9, serum amyloid A (SAA), transforming growth factor beta-1, -2, -3 (TGFβ-1, -2, -3), and tumor necrosis factor-alpha in the AH were significantly higher in patients with clinically inactive JIAUwG or JIAUwoG. Samples from JIAwoG patients displayed significantly higher levels of SAA (P < 0.0116) than JIAUwG patients. JIAUwG patients showed an increased level of TGFβ-2 in AH samples compared with JIAUwoG (P < 0.0009). These molecules may contribute to the clinical development of glaucoma in patients with JIAU.
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影响因子：
2.4
作者：
Jung, Sang Youn;Park, Min-Chan;Park, Yong-Beom;Lee, Soo-Kon
通讯作者：
Lee, Soo-Kon
影响因子：
3.4
作者：
Fuchshofer, Rudolf;Stephan, Dietrich A.;Russell, Paul;Tamm, Ernst R.
通讯作者：
Tamm, Ernst R.
影响因子：
4.6
作者：
Cheon, H;Yu, SJ;Sohn, J
通讯作者：
Sohn, J
影响因子：
4.4
作者：
Bachmann, Bjoern;Birke, Marco;Luetjen-Drecoll, Elke
通讯作者：
Luetjen-Drecoll, Elke
DOI：
10.1006/clin.1997.4409
发表时间：
1997-09-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
Letterio, JJ;Roberts, AB
通讯作者：
Roberts, AB