Serum amyloid a as a useful indicator of disease activity in patients with ankylosing spondylitis.
Serum amyloid a as a useful indicator of disease activity in patients with ankylosing spondylitis.
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DOI：
10.3349/ymj.2007.48.2.218
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发表时间：
2007-04-30
影响因子：
2.4
通讯作者：
Lee, Soo-Kon
中科院分区：
文献类型：
--
作者：
Jung, Sang Youn;Park, Min-Chan;Park, Yong-Beom;Lee, Soo-Kon
探讨强直性脊柱炎（AS）患者血清淀粉样蛋白A （SAA）水平是否升高，以及其水平是否与AS疾病活动密切相关。38名AS患者和38名年龄和性别匹配的对照组被纳入这项横断面研究。免疫比浊法定量测定SAA水平。一种已建立的、自我管理的疾病活动性评估工具（巴斯强直性脊柱炎疾病活动性指数，BASDAI）用于测量AS患者的急性期反应物，包括红细胞沉降率（ESR）和c反应蛋白（CRP）。AS患者的平均SAA水平显著高于对照组（9.52±7.49 mg/L vs 2.73±1.57 mg/L, p < 0.05），且SAA水平升高患者的平均BASDAI评分显著高于SAA水平正常患者（5.6±1.3 vs 4.4±1.5,p < 0.05）。SAA水平与BASDAI评分（r = 0.431, p = 0.007）、ESR （r = 0.521, p = 0.001）、CRP水平（r = 0.648, p < 0.001）呈显著相关。此外，ESR与CRP水平也有显著相关性（r = 0.703, p < 0.001）。在ESR或CRP水平正常的患者中，SAA水平和BASDAI评分均升高（p < 0.05），且呈正相关趋势。我们的数据显示，SAA水平在AS患者中升高，并且与疾病活动密切相关。这些发现表明SAA可以作为as疾病活动性的一个有价值的指标。
To investigate whether serum amyloid A (SAA) levels are increased in patients with ankylosing spondylitis (AS) and whether its levels correlate well with AS disease activity. Thirty-eight patients with AS and 38 age- and sex-matched control subjects were enrolled in this cross-sectional study. Their SAA levels were quantitatively measured by immunonephelometry. An established, self-administered instrument for evaluating disease activity (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI) was used to measure and acute phase reactants, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), in patients with AS. Patients with AS had a significantly higher mean SAA level than controls (9.52 ± 7.49 mg/L versus 2.73 ± 1.57 mg/L, p < 0.05), and the mean BASDAI score of patients with elevated SAA levels was significantly higher than that of patients with normal SAA levels (5.6 ± 1.3 versus 4.4 ± 1.5, p < 0.05). SAA levels showed significant correlations with BASDAI scores (r = 0.431, p = 0.007), ESR (r = 0.521, p = 0.001) and CRP levels (r = 0.648, p < 0.001). Additionally, the correlation between ESR and CRP levels also appeared significant (r = 0.703, p < 0.001). In those with normal ESR or CRP levels, SAA levels and BASDAI scores were elevated (p < 0.05) and showed a trend of positive correlation with one another. Our data showed that SAA levels were increased in patients with AS and correlated well with disease activity. These findings suggest that SAA can be used as a valuable indicator of disease activity in AS.
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影响因子：
5.1
作者：
DOWTON, SB;PETERS, CN;JESTUS, JJ
通讯作者：
JESTUS, JJ
DOI：
10.1016/j.bbrc.2003.12.096
发表时间：
2004-02-06
影响因子：
3.1
作者：
Hagihara, K;Nishikawa, T;Yoshizaki, K
通讯作者：
Yoshizaki, K
影响因子：
4
作者：
Lange, U;Boss, B;Neeck, G
通讯作者：
Neeck, G
影响因子：
3.7
作者：
MARHAUG, G
通讯作者：
MARHAUG, G
影响因子：
3.7
作者：
Strissel, KJ;Girard, MT;Fini, ME
通讯作者：
Fini, ME