Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
复制标题
患有髋部骨折的老年女性维生素 K1 和 K2 的循环水平下降
DOI：
--
复制
发表时间：
1993
影响因子：
6.2
通讯作者：
P. Delmas
中科院分区：
文献类型：
--
作者：
S. Hodges;K. Åkesson;P. Vergnaud;K. Obrant;P. Delmas
我们测量了51名平均年龄为81岁的女性髋部骨折后几小时内叶绿醌（维生素K1）和甲基萘醌（MK‐7和MK‐8）的血清水平。从同一人群中随机选择38名年龄匹配的健康女性作为对照组。髋部骨折患者血清维生素K1（336±302比585±490 pg/ml， p < 0.01）、MK‐7（120±84比226±178 pg/ml， p < 0.001）和MK‐8（89±113比161±145 pg/ml， p < 0.01）明显降低，而且大量患者血清维生素K1水平无法检测，尤其是MK‐8。维生素K水平与骨折后的时间、血清皮质醇或其他生化变量无关。这些数据表明，髋部骨折患者存在维生素K缺乏症，这种异常可能通过骨中含玻璃蛋白的γ羧化损伤影响骨代谢。
We measured the serum levels of phylloquinone (vitamin K1) and of the menaquinones, MK‐7 and MK‐8, in a group of 51 women with a mean age of 81 years who were studied within a few hours after a hip fracture. A group of 38 healthy age‐matched women randomly chosen from the same population served as controls. Patients with hip fracture had a marked reduction in serum vitamin K1 (336 ± 302 versus 585 ± 490 pg/ml, p < 0.01), MK‐7 (120 ± 84 versus 226 ± 178 pg/ml, p < 0.001), and MK‐8 (89 ± 113 versus 161 ± 145 pg/ml, p < 0.01), and a large number had undetectable levels, especially of MK‐8. Vitamin K levels were not correlated with the time elapsed after fracture or with serum cortisol or other biochemical variables. These data suggest that patients with hip fracture have vitamin K deficiency, an abnormality that could affect bone metabolism through an impairment of the gamma carboxylation of the gla‐containing proteins of bone.
DOI：
10.1073/pnas.79.24.7734
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
PRICE, PA;WILLIAMSON, MK;JEE, WSS
通讯作者：
JEE, WSS