Circle Method for Robust Estimation of Local Conduction Velocity High-Density Maps From Optical Mapping Data: Characterization of Radiofrequency Ablation Sites.
Circle Method for Robust Estimation of Local Conduction Velocity High-Density Maps From Optical Mapping Data: Characterization of Radiofrequency Ablation Sites.
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DOI：
10.3389/fphys.2022.794761
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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传导速度（CV）减慢与房颤（AF）和折返性室性心动过速（VT）相关。用于定位作为消融靶点的AF或VT源的临床电解剖标测系统仍然受到测量电极数量和信号处理方法的限制，无法生成异质性心房或小梁化心室内膜的高密度局部激动时间（LAT）和CV标测图。双极电描记图的形态和振幅取决于传播电波前的方向，使得识别通常与纤维化区域相关的低振幅信号源变得困难。相比之下，单极电描记图对波前方向不敏感，但测量结果易受远端活动的影响。本研究提出了一种从光学测绘测量中计算局部CV的方法，称为圆法（CM）。局部CV被获得为沿着跨越以CV测量位置为中心的预定义半径的圆的沿着不同弦计算的CV值的加权和。由于LAT差异的明显最大值是沿着与传播波前垂直的弦，因此该方法自适应于传播波前方向的变化，适用于异质性心肌的电导率表征。在数值模拟中，CM得到验证，将建模消融区域表征为不同CV减慢的区域。在实验上，CM被用来表征射频消融（RFA）对大鼠、豚鼠和离体人心脏造成的损伤。为了推断射频消融产生的损伤的深度，使用不同穿透深度的激发光带，并进行逐搏CV差异分析以识别CV交替。尽管仅限于实验室研究，但基于CM和光学标测的研究可能会导致对更好的引导消融治疗的新的翻译见解。
Conduction velocity (CV) slowing is associated with atrial fibrillation (AF) and reentrant ventricular tachycardia (VT). Clinical electroanatomical mapping systems used to localize AF or VT sources as ablation targets remain limited by the number of measuring electrodes and signal processing methods to generate high-density local activation time (LAT) and CV maps of heterogeneous atrial or trabeculated ventricular endocardium. The morphology and amplitude of bipolar electrograms depend on the direction of propagating electrical wavefront, making identification of low-amplitude signal sources commonly associated with fibrotic area difficulty. In comparison, unipolar electrograms are not sensitive to wavefront direction, but measurements are susceptible to distal activity. This study proposes a method for local CV calculation from optical mapping measurements, termed the circle method (CM). The local CV is obtained as a weighted sum of CV values calculated along different chords spanning a circle of predefined radius centered at a CV measurement location. As a distinct maximum in LAT differences is along the chord normal to the propagating wavefront, the method is adaptive to the propagating wavefront direction changes, suitable for electrical conductivity characterization of heterogeneous myocardium. In numerical simulations, CM was validated characterizing modeled ablated areas as zones of distinct CV slowing. Experimentally, CM was used to characterize lesions created by radiofrequency ablation (RFA) on isolated hearts of rats, guinea pig, and explanted human hearts. To infer the depth of RFA-created lesions, excitation light bands of different penetration depths were used, and a beat-to-beat CV difference analysis was performed to identify CV alternans. Despite being limited to laboratory research, studies based on CM with optical mapping may lead to new translational insights into better-guided ablation therapies.
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DOI：
10.1111/j.1540-8159.1987.tb05974.x
发表时间：
1987-03-01
影响因子：
1.8
作者：
ELSHERIF, N;GOUGH, WB;RESTIVO, M
通讯作者：
RESTIVO, M
影响因子：
37.8
作者：
Aziz, Zaid;Shatz, Dalise;Tung, Roderick
通讯作者：
Tung, Roderick
影响因子：
4.6
作者：
Gloschat, Christopher;Aras, Kedar;Efimov, Igor R.
通讯作者：
Efimov, Igor R.
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR
影响因子：
4.6
作者：
Bayly, PV;KenKnight, BH;Smith, WM
通讯作者：
Smith, WM