Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats.
Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats.
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雌性大鼠视前区性二形核性别分化的激素敏感围产期的开始。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
R. Gorski
中科院分区：
文献类型：
--
作者：
R. W. Rhees;J. Shryne;R. Gorski
雄性大鼠脑视前区性别二态核（SDN-POA）的体积比雌性大几倍。在围产期脑性别分化的“关键时期”，激素环境对SDN-POA的体积有显著影响。本研究的目的是确定SDN-POA性别分化时期的开始。妊娠大鼠不接受任何治疗，或在妊娠第17、18、20天皮下注射油，或在妊娠第16-22天皮下注射睾酮（T;5 mg）。在出生后第15天，在第16或17天前暴露于睾酮的雌性后代的单侧SDN-POA体积与对照组（未治疗或注射油）后代的值没有差异。在妊娠第18、19和20天，雌性雌性小鼠的SDN-POA体积比对照动物的SDN-POA体积显著增加。在第21天和第22天，雌性后代的SDN-POA体积虽然大于对照组，但没有统计学差异。我们得出的结论是，在本研究中使用的特定范例中，SDN-POA的发展在妊娠第18天之前是不敏感的，这一天是激素敏感期的开始。
The volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the rat brain is severalfold larger in males than in females. The volume of the SDN-POA can be influenced significantly by the hormonal milieu during the perinatal "critical period" of sexual differentiation of the brain. The purpose of the present study was to determine the onset of this period of sexual differentiation of the SDN-POA. Pregnant rats received no treatment or were injected subcutaneously with oil on day 17, 18, or 20, or testosterone (T;5 mg) on days 16-22 of gestation. On postnatal day 15, unilateral SDN-POA volumes from female offspring prenatally exposed to testosterone on day 16 or 17 were not different from values of control (untreated or oil-injected) offspring. Female offspring from mothers treated with testosterone on day 18, 19, or 20 of gestation showed a significant and similar increase in SDN-POA volume over values from control animals. SDN-POA volumes from female offspring exposed to testosterone on day 21 or 22, although larger than those of controls, were not different statistically. We conclude that with the specific paradigm used in this study SDN-POA development is insensitive prior to day 18 of gestation, the day on which the onset of the hormone-sensitive period occurs.
雄性和雌性大鼠视前区性二形核分化的激素敏感期的终止。
DOI：
10.1016/0165-3806(90)90217-m
发表时间：
1990
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Rhees,RW;Shryne,JE;Gorski,RA
通讯作者：
Gorski,RA
产前和新生儿雄激素暴露相互作用，影响雌性大鼠的性别分化。
影响因子：
1.9
作者：
Hoepfner,BA;Ward,IL
通讯作者：
Ward,IL