Occupational exposure to organic dust increases lung cancer risk in the general population.
Occupational exposure to organic dust increases lung cancer risk in the general population.
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DOI：
10.1136/thoraxjnl-2011-200716
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发表时间：
2012-03
期刊：
影响因子：
10
通讯作者：
Vermeulen R
中科院分区：
文献类型：
--
作者：
Peters S;Kromhout H;Olsson AC;Wichmann HE;Brüske I;Consonni D;Landi MT;Caporaso N;Siemiatycki J;Richiardi L;Mirabelli D;Simonato L;Gustavsson P;Plato N;Jöckel KH;Ahrens W;Pohlabeln H;Boffetta P;Brennan P;Zaridze D;Cassidy A;Lissowska J;Szeszenia-Dabrowska N;Rudnai P;Fabianova E;Forastiere F;Bencko V;Foretova L;Janout V;Stücker I;Dumitru RS;Benhamou S;Bueno-de-Mesquita B;Kendzia B;Pesch B;Straif K;Brüning T;Vermeulen R
Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (e.g. endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population. The SYNERGY project has pooled information on lifetime working and smoking from 13,300 lung cancer cases and 16,273 controls from 11 case-control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low, or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. Odds ratios for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time-since-quitting smoking, and ever employment in occupations with established lung cancer risk. Occupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p-value <.001). This association remained in the highest quartile after restricting analyses to subjects without COPD or asthma. No association was observed between lung cancer and exposure to endotoxin or contact with animals or animal products. Occupational exposure to organic dust was associated with increased lung cancer risk in this large pooled case-control study.
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影响因子：
10
作者：
Purdue, Mark P.;Gold, Laura;Vermeulen, Roel
通讯作者：
Vermeulen, Roel
影响因子：
10.3
作者：
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影响因子：
3.5
作者：
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Spitz, MR
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作者：
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通讯作者：
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影响因子：
4.9
作者：
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通讯作者：
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