Chelates of gadolinium and dysprosium as contrast agents for MR imaging
Chelates of gadolinium and dysprosium as contrast agents for MR imaging
复制标题
钆和镝的螯合物作为 MR 成像造影剂
DOI：
--
复制
发表时间：
1993
影响因子：
4.4
通讯作者：
A. Watson
中科院分区：
文献类型：
--
作者：
S. Rocklage;A. Watson
THE RECOGNITION OF the importance of magnetic materials and their effect on the relaxation times of resonating protons occurred simultaneously with the discovery of the magnetic resonance (MR) phenomenon by Bloch in 1946 (1). In early studies, paramagnetic ferric ions in solution were shown to reduce the T1 of protons in water. Solomon (2) in 1955 and Blo-embergen (3) in 1957 extended this work to avariety of paramagnetic transition metals. Throughout the 1960s and 1970s, the ongoing development of paramagnetic shift reagents (4-7) and relaxation probes (8,!3) contributed greatly to the development of nuclear MR spectroscopy. development of the MR imaging technique (10) and the early development of contrast agents. By 1978, paramagnetic ions and chelate complexes were being used to alter relaxation times in canine cardiac tissues(11). Elarly animal and human MR imaging studies that used simple metal ion salts ( 1 1.12) and chelates ( 13-15) as contrast agents led rapidly to the recognition that these agents could readily enhance inherently excellent MR imaging resolution. These studies also revealed the potential for coupling MR imaging with true functional or metabolic imaging. Paul Lauterbur was responsible for both the initial
影响因子：
6.7
作者：
O. Clément;A. Mühler;V. Vexler;Y. Berthezène;R. Brasch
通讯作者：
O. Clément;A. Mühler;V. Vexler;Y. Berthezène;R. Brasch
金属卟啉在磁共振成像中增强肿瘤的对比度。
影响因子：
6.7
作者：
Ogan,MD;Revel,D;Brasch,RC
通讯作者：
Brasch,RC