Risk factors for failure of initial intravenous immunoglobulin treatment in Kawasaki disease.
Risk factors for failure of initial intravenous immunoglobulin treatment in Kawasaki disease.
复制标题
川崎疾病中初始静脉免疫球蛋白治疗失败的危险因素。
DOI：
10.3346/jkms.2008.23.4.718
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发表时间：
2008-08
影响因子：
4.5
通讯作者：
Yoon KL
中科院分区：
文献类型：
--
作者：
Cha S;Yoon M;Ahn Y;Han M;Yoon KL
本研究的目的是确定与川崎病 (KD) 初始静脉注射免疫球蛋白 (IVIG) 治疗失败相关的发生率和变量，并对初始 IVIG 治疗有反应者和无反应者之间的临床特征差异进行分类。患者被分为两组。 A 组包括 33 名接受单剂 IVIG 治疗并有反应的患者。 B组包括18名因初始治疗失败而接受超过两剂IVIG的患者。 B 组初始治疗后的平均发热持续时间明显长于 A 组。在 B 组中，我们发现基线时较高的胆红素、天冬氨酸转氨酶 (AST)、多形核细胞 (PMN) (%) 和较低的血小板值是 KD 患者持续或反复发热的独立预测因素。 B 组有 8 名患者（44.4%）发现冠状动脉异常，A 组有 2 名患者（6.1%）发现冠状动脉异常。我们发现肝功能测试异常和基线时血小板计数较低可能是 KD 患者对 IVIG 无反应的可能预测因素。需要针对基线肝胆参数进行前瞻性研究。
The aims of this study were to determine the occurrence and variables associated with the initial intravenous immunoglobulin (IVIG) treatment failure in Kawasaki disease (KD) and to categorize differences in clinical characteristics between responders and nonresponders to initial IVIG treatment. Patients were classified into two groups. Group A included 33 patients who received a single dose of IVIG treatment and responded. Group B included 18 patients who received more than two doses of IVIG due to failure of the initial treatment. The mean duration of fever after initial treatment in group B was significantly longer than it was in group A. In group B, we found that higher bilirubin, aspartate aminotransferase (AST), polymorphonuclear cells (PMN) (%), and lower platelet values at baseline were independent predictors of persistent or recurrent fever in patients with KD. Coronary artery abnormalities were found in 8 patients (44.4%) in group B and in two patients (6.1%) in group A. We found that abnormal liver function tests and a lower platelet count at baseline were possible predictors of nonresponders to IVIG in patients with KD. There is a need for a prospective study focused on baseline hepatobiliary parameters.
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影响因子：
37.8
作者：
Kobayashi, Tohru;Inoue, Yoshinari;Morikawa, Akihiro
通讯作者：
Morikawa, Akihiro
影响因子：
8
作者：
Wallace, CA;French, JW;Sherry, DD
通讯作者：
Sherry, DD
影响因子：
1.4
作者：
Park, YW;Han, JW;Tockgo, YC
通讯作者：
Tockgo, YC
影响因子：
3.6
作者：
Burns, JC;Capparelli, EV;Glode, MP
通讯作者：
Glode, MP
DOI：
10.1016/s0735-1097(86)80390-4
发表时间：
1986-11-01
影响因子：
24
作者：
ARJUNAN, K;DANIELS, SR;KAPLAN, S
通讯作者：
KAPLAN, S