Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization
Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization
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通过比较基因组杂交鉴定套细胞淋巴瘤 DNA 中新的扩增和缺失区域
DOI：
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发表时间：
2002
影响因子：
6.5
通讯作者：
D. Hammond
中科院分区：
文献类型：
--
作者：
Jeannette E. Allen;Rachael E. Hough;J. Goepel;S. Bottomley;G. Wilson;H. Alcock;M. Baird;P. Lorigan;E. Vandenberghe;B. Hancock;D. Hammond
总结。我们对30例英国套细胞淋巴瘤的档案活检材料进行比较基因组杂交(CGH)分析。最常见的异常是3q(21例)、6p(19例)、7q(8例)、12p(8例)、12q(9例)和17q11q21(8例)，1p13p32(10例)、5p13p15.3(9例)、6q14q27(11例)、8p(7例)、11q13q23(8例)和13q(18例)丢失。19例(63%)在3q28q29有共同扩增区，其中3例高度扩增，提示该区域存在套细胞淋巴瘤相关癌基因。有9例(30%)在6q25q26有一个最小共同缺失区域。以前在6号染色体上还没有发现MCL特异性基因，该区域可能含有一个肿瘤抑制基因，该基因与该亚型淋巴瘤的发生有关。染色体畸变数的增加、Xq的增加和17p的丢失都与较差的预后显著相关。更多地了解套细胞淋巴瘤的遗传学可能有助于确定预后因素，从而有助于确定适当的治疗方案。
Summary. We have carried out comparative genomic hybridization (CGH) analysis on archival biopsy material from a series of 30 UK mantle cell lymphomas. The most frequent aberrations were gains of 3q (21 cases), 6p (19 cases), 7q (8 cases), 12p (8 cases), 12q (9 cases) and 17q11q21 (8 cases), and losses of 1p13p32 (10 cases), 5p13p15.3 (9 cases), 6q14q27 (11 cases), 8p (7 cases), 11q13q23 (8 cases) and 13q (18 cases). Nineteen cases (63%) had a common region of amplification at 3q28q29, which was highly amplified in three cases, suggesting the presence of a mantle cell lymphoma (MCL)‐related oncogene in this region. There was a minimal common region of deletion at 6q25q26 in nine cases (30%). No MCL‐specific locus has previously been identified on chromosome 6 and this region may contain a tumour suppressor gene specifically implicated in the development of this subtype of lymphoma. An increased number of chromosome aberrations, gain of Xq and loss of 17p were all significantly associated with a worse prognosis. A greater understanding of the genetics of mantle cell lymphoma may allow the identification of prognostic factors which will aid the identification of appropriate treatment regimens.
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影响因子：
20.3
作者：
Greiner, TC;Moynihan, MJ;Weisenburger, DD
通讯作者：
Weisenburger, DD
中心细胞淋巴瘤中的染色体 t(11;14)(q13;q32) 断点高度集中于 bcl-1 主要易位簇。
影响因子：
11.4
作者：
Williams,ME;Swerdlow,SH;Meeker,TC
通讯作者：
Meeker,TC
影响因子：
20.3
作者：
FISHER, RI;DAHLBERG, S;GROGAN, TM
通讯作者：
GROGAN, TM
影响因子：
56.9
作者：
KALLIONIEMI, A;KALLIONIEMI, OP;PINKEL, D
通讯作者：
PINKEL, D