Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition.
Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition.
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DOI：
10.1016/j.dental.2011.03.016
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发表时间：
2011-08
期刊：
影响因子：
5
通讯作者：
Chow, Laurence C.
中科院分区：
文献类型：
--
作者：
Xu, Hockin H. K.;Moreau, Jennifer L.;Sun, Limin;Chow, Laurence C.
关键词：
复合材料牙釉质修复面临的主要挑战是继发龋和大块骨折。本研究的目的是合成新型无定形磷酸钙（NACP）纳米颗粒，开发具有钙（Ca）和磷酸盐（PO 4）离子释放的NACP纳米复合材料以对抗龋齿，并研究NACP填料水平和玻璃共填料增强对复合材料性能的影响。首次采用喷雾干燥法合成了NACP（直径= 116 nm）。由于口腔中的局部菌斑pH可降低至5或4，因此将光活化复合材料浸入pH 7、5.5和4的溶液中进行测试。复合材料的机械性能，以及钙和PO 4离子的释放进行了测量与pH值和填料水平。增加NACP填料水平增加了离子释放。28 d时，pH 4时，20%NACP组的钙释放量为（4.66 ± 0.05）mmol/L，显著高于10%NACP组的（0.33 ± 0.08）mmol/L（p < 0.05）。降低pH增加了离子释放。在20%NACP条件下，pH 4时28 d的PO 4释放量为（1.84 ± 0.12）mmol/L，高于pH 5.5时的（0.59 ± 0.08）mmol/L和pH 7时的（0.12 ± 0.01）mmol/L（p < 0.05）。pH值对复合材料的力学性能影响不大。在pH 4时，15%NACP的弯曲强度为（96 ± 13）MPa，与pH 5.5时的（89 ± 13）MPa和pH 7时的（89 ± 19）MPa相似（p > 0.1）。新的NACP纳米复合材料的强度是以前的磷酸钙复合材料和树脂改性玻璃离子对照的2倍。NACP复合材料是首次开发。它们的强度与商业复合材料相当或超过商业复合材料，几乎没有离子释放，是以前Ca-PO 4复合材料的2倍。纳米复合材料是“智能”的，因为它大大增加了在致龋pH 4下的离子释放，而此时最需要这些离子来抑制龋齿。因此，新的NACP复合材料可能是有前途的应力轴承和龋齿抑制的解释。
The main challenges facing composite restorations are secondary caries and bulk fracture. The objectives of this study were to synthesize novel nanoparticles of amorphous calcium phosphate (NACP), develop NACP nanocomposite with calcium (Ca) and phosphate (PO4) ion release to combat caries, and investigate the effects of NACP filler level and glass co-filler reinforcement on composite properties. NACP (diameter = 116 nm) were synthesized via a spray-drying technique for the first time. Since the local plaque pH in the oral cavity can decrease to 5 or 4, photo-activated composites were tested with immersion in solutions of pH 7, 5.5, and 4. Composite mechanical properties as well as Ca and PO4 ion release were measured vs. pH and filler level. Increasing the NACP filler level increased the ion release. At 28 d and pH 4, the Ca release was (4.66 ± 0.05) mmol/L at 20% NACP, much higher than (0.33 ± 0.08) at 10% NACP (p < 0.05). Decreasing the pH increased the ion release. At 20% NACP, the PO4 release at 28 d was (1.84 ± 0.12) mmol/L at pH 4, higher than (0.59 ± 0.08) at pH 5.5, and (0.12 ± 0.01) at pH 7 (p < 0.05). However, pH had little effect on composite mechanical properties. Flexural strength at 15% NACP was (96 ± 13) MPa at pH 4, similar to (89 ± 13) MPa at pH 5.5, and (89 ± 19) MPa at pH 7 (p > 0.1). The new NACP nanocomposites had strengths that were 2-fold those of previous calcium phosphate composites and resin-modified glass ionomer control. NACP composites were developed for the first time. Their strengths matched or exceeded a commercial composite with little ion release, and were 2-fold those of previous Ca-PO4 composites. The nanocomposite was “smart” as it greatly increased the ion release at a cariogenic pH 4, when these ions would be most needed to inhibit caries. Hence, the new NACP composite may be promising for stress-bearing and caries-inhibiting restorations.
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影响因子：
5
作者：
Lim, BS;Ferracane, JL;Condon, JR
通讯作者：
Condon, JR
影响因子：
5
作者：
Della Bona, Alvaro;Mecholsky, John J., Jr.;Barrett, Allyson A.;Griggs, Jason A.
通讯作者：
Griggs, Jason A.
影响因子：
5
作者：
Drummond, JL;Bapna, MS
通讯作者：
Bapna, MS
DOI：
10.6028/jres.109.041
发表时间：
2004-11
影响因子：
1.5
作者：
Chow LC;Sun L;Hockey B
通讯作者：
Hockey B
影响因子：
--
作者：
Griggs, Jason A
通讯作者：
Griggs, Jason A