PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.
PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.
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DOI：
10.1016/j.exphem.2018.03.001
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发表时间：
2018-06
影响因子：
2.6
通讯作者：
Young NS
中科院分区：
文献类型：
--
作者：
Hollinger MK;Giudice V;Cummings NA;Rivell G;Zhang H;Kajigaya S;Keyvanfar K;Chen J;Feng X;Young NS
While PD-1 blockade has revolutionized cancer immunotherapy, immune-related adverse events (irAEs) present life-threatening complications. Recent reports of aplastic anemia (AA) as irAEs implicate PD-1/PD-L1 as important in preventing immune-mediated destruction of the hematopoietic niche. Infusion of PD-1-deficient (PD-1 KO) lymph node (LN) cells into minor-antigen mismatched mice resulted in early mortality, as well as more severe BM hypoplasia, anemia, and BM microarchitecture disruption in PD-1 KO LN-infused mice relative to mice that received B6 LN cell infusion. Mice that received PD-1 KO LN cells had more CD8+ T cell infiltration of the BM and greater expansion of H60-specific CD8+ T cells than did their B6 LN-infused counterparts. In the spleen, CD8+ T cells were skewed to an effector memory phenotype, suggesting accelerated differentiation of PD-1 KO T cells. Our data suggest that PD-1 dysregulation has a role in murine BM failure, and vigilance in irAE monitoring may be desirable to treat early AA and related cytopenias.
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影响因子：
5.6
作者：
Kumar V;Chaudhary N;Garg M;Floudas CS;Soni P;Chandra AB
通讯作者：
Chandra AB
影响因子：
4.4
作者：
Chen, Jichun;Ellison, Felicia M.;Young, Neal S.
通讯作者：
Young, Neal S.
影响因子：
2.3
作者：
Turgeman, Ilit;Wollner, Mira;Bar-Sela, Gil
通讯作者：
Bar-Sela, Gil
影响因子：
4.4
作者：
Blazar, BR;Carreno, BM;Taylor, PA
通讯作者：
Taylor, PA
DOI：
10.4049/jimmunol.1402180
发表时间：
2015-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Tkachev V;Goodell S;Opipari AW;Hao LY;Franchi L;Glick GD;Ferrara JL;Byersdorfer CA
通讯作者：
Byersdorfer CA