Pro-resolving mediators in the regulation of periodontal disease.
Pro-resolving mediators in the regulation of periodontal disease.
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DOI：
10.1016/j.mam.2017.04.006
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发表时间：
2017-12
影响因子：
10.6
通讯作者：
Van Dyke TE
中科院分区：
文献类型：
--
作者：
Van Dyke TE
牙周炎是由细菌在牙齿表面形成生物膜引起的牙列支撑结构的炎性疾病。该疾病的发病机制是生物膜和宿主反应之间复杂相互作用的结果，其导致微生物组的生态失调和炎症反应的失调。目前的数据表明，与牙周炎相关的过度炎症是由于炎症途径的解决失败。在这篇综述中，炎症和微生物生态失调之间的关系进行了检查的背景下，促炎症和促决议介质和他们的能力，以修改疾病的过程。本文综述了局部口腔炎症对全身炎症的影响以及牙周炎与其他炎症性疾病（包括2型糖尿病和心血管疾病）的关系。炎症的活性消退剂，包括脂氧素和消退素，显示出作为治疗牙周炎和其他炎性疾病的治疗剂的巨大前景。
Periodontitis is an inflammatory disease of the supporting structures of the dentition that is initiated by bacterial that form a biofilm on the surface of the teeth. The pathogenesis of the disease is a result of complex interactions between the biofilm and the host response that results in dysbiosis of the microbiome and dysregulation of the inflammatory response. Current data suggest that the excess inflammation associated with periodontitis is due to a failure of resolution of inflammation pathways. In this review, the relationship between inflammation and microbial dysbiosis is examined in the context of pro-inflammation and pro-resolution mediators and their ability to modify the course of disease. The impact of local oral inflammation on systemic inflammation and the relationship of periodontitis to other inflammatory diseases, including type 2 diabetes and cardiovascular disease is reviewed. Active resolvers of inflammation, including the lipoxins and resolvins, show great promise as therapeutics for the treatment of periodontitis and other inflammatory diseases.
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影响因子：
5.1
作者：
Bzowska, Malgorzata;Nogiec, Anna;Skrzeczynska-Moncznik, Joanna;Mickowska, Barbara;Guzik, Krzysztof;Pryjma, Juliusz
通讯作者：
Pryjma, Juliusz
影响因子：
7.1
作者：
BANG, HO;DYERBERG, J;SINCLAIR, HM
通讯作者：
SINCLAIR, HM
影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
7.7
作者：
Campbell LA;Rosenfeld ME
通讯作者：
Rosenfeld ME
影响因子：
4.4
作者：
Arita, Makoto;Ohira, Taisuke;Serhan, Charles N.
通讯作者：
Serhan, Charles N.