Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine
Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine
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细菌感染小鼠肠道中乳铁蛋白的分布与中性粒细胞动态相关
DOI：
10.3390/molecules25071496
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发表时间：
2020-03
期刊：
影响因子：
4.6
通讯作者：
Du Hua-Hua
中科院分区：
文献类型：
--
作者：
Liang Li;Wang Zhen-Jie;Ye Guang;Tang Xue-You;Zhang Yuan-Yuan;Kong Jing-Xia;Du Hua-Hua
Lactoferrin (Lf) is a conserved iron-binding glycoprotein with antimicrobial activity, which is present in secretions that recover mucosal sites regarded as portals of invaded pathogens. Although numerous studies have focused on exogenous Lf, little is known about its expression of endogenous Lf upon bacterial infection. In this study, we investigated the distribution of Lf in mice intestine during Escherichia coli (E. coli) K88 infection. PCR and immunohistology staining showed that mRNA levels of Lf significantly increased in duodenum, ileum and colon, but extremely decreased in jejunum at 8 h and 24 h after infection. Meanwhile, endogenous Lf was mostly located in the lamina propria of intestine villi, while Lf receptor (LfR) was in the crypts. It suggested that endogenous Lf-LfR interaction might not be implicated in the antibacterial process. In addition, it was interesting to find that the infiltration of neutrophils into intestine tissues was changed similarly to Lf expression. It indicated that the variations of Lf expression were rather due to an equilibrium between the recruitment of neutrophils and degranulation of activated neutrophils. Thus, this new knowledge will pave the way to a more effective understanding of the role of Lf in intestinal mucosal immunity.
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影响因子：
4.6
作者：
Wisgrill L;Wessely I;Spittler A;Förster-Waldl E;Berger A;Sadeghi K
通讯作者：
Sadeghi K
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影响因子：
4.2
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影响因子：
2.1
作者：
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通讯作者：
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影响因子：
3
作者：
Embleton, Nicholas D.;Berrington, Janet E.;Cummings, Stephen P.
通讯作者：
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影响因子：
4.5
作者：
Ahmed I;Roy BC;Khan SA;Septer S;Umar S
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