Molecular paleontology and complexity in the last eukaryotic common ancestor.
Molecular paleontology and complexity in the last eukaryotic common ancestor.
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DOI：
10.3109/10409238.2013.821444
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发表时间：
2013-07
影响因子：
6.5
通讯作者：
Field MC
中科院分区：
文献类型：
--
作者：
Koumandou VL;Wickstead B;Ginger ML;van der Giezen M;Dacks JB;Field MC
真核发生，即真核细胞的起源，代表了地球生命史上最基本的进化转变之一。据估计，这一事件发生在10亿多年前，但人们对它的了解仍然很少。虽然已经描述了一些在这个时间框架内得到充分验证的化石微生物真核生物的例子，但这些例子只能提供基本形态，并且这些生物中存在的分子机制仍然未知。完整和部分的基因组信息已经开始填补这一空白，并被用于追踪蛋白质和细胞特征的根源，并在真核谱系的这些早期点上提供生物体结构，代谢途径和能力的前所未有的分辨率。这就使得分子古生物学成为可能。从这些研究中得出的结论是，在真核生物谱系扩展之前，细胞的复杂性是惊人的。多个重建的细胞系统表明了一个非常复杂的生物学，这意味着在最初的真核发生事件之后出现，但在真核辐射之前出现，并在解释这些早期真核生物如何产生和理解它们如何生活方面提出了挑战。在这里，我们简要概述了几种细胞系统和主要的新兴结论，并预测了导致现存分类群的后续进化方向。我们还考虑了这些重建对这些最早的真核生物的生活方式和能力以及真核生物辐射和真核发生事件本身之间的进化时期的启示。
Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental evolutionary transitions in the history of life on earth. This event, which is estimated to have occurred over one billion years ago, remains rather poorly understood. While some well-validated examples of fossil microbial eukaryotes for this time frame have been described, these can provide only basic morphology and the molecular machinery present in these organisms has remained unknown. Complete and partial genomic information has begun to fill this gap, and is being used to trace proteins and cellular traits to their roots and to provide unprecedented levels of resolution of structures, metabolic pathways and capabilities of organisms at these earliest points within the eukaryotic lineage. This is essentially allowing a molecular paleontology. What has emerged from these studies is spectacular cellular complexity prior to expansion of the eukaryotic lineages. Multiple reconstructed cellular systems indicate a very sophisticated biology, which by implication arose following the initial eukaryogenesis event but prior to eukaryotic radiation and provides a challenge in terms of explaining how these early eukaryotes arose and in understanding how they lived. Here, we provide brief overviews of several cellular systems and the major emerging conclusions, together with predictions for subsequent directions in evolution leading to extant taxa. We also consider what these reconstructions suggest about the life styles and capabilities of these earliest eukaryotes and the period of evolution between the radiation of eukaryotes and the eukaryogenesis event itself.
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DOI：
10.1073/pnas.83.23.9011
发表时间：
1986-12-01
影响因子：
11.1
作者：
ALLISON, DS;SCHATZ, G
通讯作者：
SCHATZ, G
影响因子：
9.2
作者：
Azimzadeh, Juliette;Marshall, Wallace F.
通讯作者：
Marshall, Wallace F.
影响因子：
3.6
作者：
Buermann, Frank;Ebert, Nina;Bramkamp, Marc
通讯作者：
Bramkamp, Marc
DOI：
10.1073/pnas.89.16.7290
发表时间：
1992-08-15
影响因子：
11.1
作者：
BORK, P;SANDER, C;VALENCIA, A
通讯作者：
VALENCIA, A
影响因子：
--
作者：
Basu, Somsuvro;Leonard, Joanne C.;Allen, James W. A.
通讯作者：
Allen, James W. A.