Fatty acid transporting proteins: Roles in brain development, aging, and stroke.

Fatty acid transporting proteins: Roles in brain development, aging, and stroke.
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脂肪酸转运蛋白:在大脑发育、衰老和中风中的作用。

DOI:
10.1016/j.plefa.2017.04.004
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发表时间:
2018-09
期刊:
Prostaglandins, leukotrienes, and essential fatty acids
影响因子:
--
通讯作者:
Stetler RA
Stetler RA
中科院分区:
其他
文献类型:
--
作者:
Zhang W;Chen R;Yang T;Xu N;Chen J;Gao Y;Stetler RA

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多不饱和脂肪酸是大脑发育所必需的,对衰老和中风有显著影响。由于脂肪酸的疏水性,脂肪酸转运相关蛋白包括脂肪酸结合蛋白(FABPs)、长链酰基辅酶A合酶(ACS)、脂肪酸转运蛋白(FATPs)、脂肪酸转位酶(FAT/CD 36)和新报道的主要易化剂超家族含结构域蛋白(Mfsd 2a)在各种脂肪酸尤其是多不饱和脂肪酸的摄取中起关键作用。它们不仅参与神经发育,而且对神经系统疾病,如与衰老相关的痴呆和中风有很大的影响。
Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-containing protein (Mfsd2a) play critical roles in the uptake of various fatty acids, especially polyunsaturated fatty acids. They are not only involved in neurodevelopment, but also have great impact on neurological disease, such as aging related dementia and stroke.
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发表时间: 2013-05
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