Dissociative electron attachment to DNA-diamine thin films: impact of the DNA close environment on the OH- and O- decay channels.

Dissociative electron attachment to DNA-diamine thin films: impact of the DNA close environment on the OH- and O- decay channels.
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DNA-二胺薄膜上的解离电子附着:DNA 封闭环境对 OH- 和 O- 衰变通道的影响。

DOI:
10.1063/1.4815967
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发表时间:
2013
期刊:
The Journal of chemical physics
影响因子:
--
通讯作者:
L. Sanche
L. Sanche
中科院分区:
--
文献类型:
--
作者:
O. Boulanouar;M. Fromm;C. Mavon;P. Cloutier;L. Sanche

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我们测量了0-20 eV电子在质粒dna -二氨基丙烷高度均匀薄膜上刺激阴离子的解吸。原子力显微镜(AFM)和XPS测量结果与薄膜厚度和成分具有较好的相关性。H(-), O(-)和OH(-)产率函数中的共振结构归因于瞬态阴离子进入解离电子附着(DEA)通道的衰变。二胺在DNA主链上诱导磷酸铵桥,抑制了DEA O(-)通道,相应地增加了OH(-)的解吸。因此,磷酸基团的紧密环境可能在调节由低能电子引起的DNA损伤的速率和类型方面起重要作用。
We measure the desorption of anions stimulated by the impact of 0-20 eV electrons on highly uniform thin films of plasmid DNA-diaminopropane. The results are accurately correlated with film thickness and composition by AFM and XPS measurements, respectively. Resonant structures in the H(-), O(-), and OH(-) yield functions are attributed to the decay of transient anions into the dissociative electron attachment (DEA) channel. The diamine induces ammonium-phosphate bridges along the DNA backbone, which suppresses the DEA O(-) channel and in counter-part increases considerably the desorption of OH(-). The close environment of the phosphate groups may therefore play an important role in modulating the rate and type of DNA damages induced by low energy electrons.
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影响因子: 3.3
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