Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy
Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy
复制标题
解开自噬与转移之间的关系以寻找潜在的癌症治疗
DOI：
10.1007/s10495-016-1237-2
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发表时间：
2016-03
期刊：
影响因子：
7.2
通讯作者：
Wang, Jinhui
中科院分区：
文献类型：
--
作者：
Zhang, Jin;Fu, Leilei;Ouyang, Liang;Wang, Jinhui
自噬是一种高度保守的溶酶体依赖的降解过程，可能会消化一些长寿的蛋白质和受损的细胞器。自噬作为正常细胞中重要的动态平衡维持系统，在多种病理过程中发挥着重要作用，尤其是在癌症中。转移被认为是癌症进展的重要标志，是癌症致死的主要原因。自噬在转移中的作用相当复杂，因为支持证据表明自噬既有促进转移的功能，也有抗转移的功能。自噬可以通过限制坏死和介导自噬细胞死亡来抑制转移，而它也可能通过增强癌细胞对应激的适应性来促进转移。此外，自噬的功能是上下文和阶段相关的。具体地说，在转移的早期阶段，自噬主要起抑制作用，而在转移的后期起促进转移的作用。在这里，我们着重强调自噬在转移中的双重作用，并阐述参与这一过程的分子机制，这可能为癌症生物学提供新的见解。同时，我们还总结了几种操纵自噬的抗转移药物，以期对探索未来癌症治疗的潜在新药有所裨益。
Autophagy is a highly conserved lysosome-dependent degradation process that may digest some long-lived proteins and damaged organelles. As an essential homeostasis maintaining system in normal cells, autophagy plays a key role in several pathological settings, especially cancer. Metastasis, known as a crucial hallmark of cancer progression, is the primary cause of cancer lethality. The role of autophagy in metastasis is quite complex as supportive evidence has indicated both pro-metastatic and anti-metastatic functions of autophagy. Autophagy can inhibit metastasis by restricting necrosis and mediating autophagic cell death, whereas it may also promote metastasis by enhancing cancer cell fitness in response to stress. Moreover, the function of autophagy is context- and stage-dependent. Specifically, during the early steps of metastasis, autophagy mainly serves as a suppressor, while it plays a pro-metastatic role in the later steps. Here, we focus on highlighting the dual roles of autophagy in metastasis and address the molecular mechanisms involved in this process, which may provide a new insight into cancer biology. While, we also summarize several anti-metastatic agents manipulating autophagy, in the hope of shedding light on exploration of potential novel drugs for future cancer therapy.
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DOI：
10.5114/wo.2014.41395
发表时间：
2014
期刊：
Contemporary oncology (Poznan, Poland)
影响因子：
--
作者：
Chen Y;Yan J;Yu S;Wang X;Zheng Q
通讯作者：
Zheng Q
影响因子：
11.1
作者：
Tang, Hao;Sebti, Salwa;Titone, Rossella;Zhou, Yunyun;Isidoro, Ciro;Ross, Theodora S.;Hibshoosh, Hanina;Xiao, Guanghua;Packer, Milton;Xie, Yang;Levine, Beth
通讯作者：
Levine, Beth
影响因子：
9
作者：
通讯作者：
--
影响因子：
--
作者：
Bhattacharya A;Schmitz U;Raatz Y;Schönherr M;Kottek T;Schauer M;Franz S;Saalbach A;Anderegg U;Wolkenhauer O;Schadendorf D;Simon JC;Magin T;Vera J;Kunz M
通讯作者：
Kunz M
影响因子：
3.7
作者：
Jo YK;Kim SC;Park IJ;Park SJ;Jin DH;Hong SW;Cho DH;Kim JC
通讯作者：
Kim JC