Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis.
Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis.
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DOI：
10.1371/journal.pone.0052705
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kim JC
中科院分区：
文献类型：
--
作者：
Jo YK;Kim SC;Park IJ;Park SJ;Jin DH;Hong SW;Cho DH;Kim JC
自噬在肿瘤的发生发展中具有复杂而矛盾的功能，而自噬相关基因（ATG）是自噬的关键调控因子。到目前为止，已经在酵母中鉴定出30多种不同的ATG蛋白，并且它们的哺乳动物对应物也已被报道。虽然一些ATG蛋白在癌症中的作用已经被表征，但ATG 10的作用几乎完全未知。为了探讨ATG 10在结直肠癌中的临床病理作用，我们分析了ATG 10在结直肠癌组织和细胞系中的表达。蛋白质表达分析显示，ATG 10在结肠直肠癌中高度增加（组织-37例病例中的18例，48%;细胞系-12例细胞系中的8例，66%）。免疫组化结合临床病理特征分析表明，ATG 10的上调与肿瘤淋巴结转移（p = 0.005）和浸润（p<0.001）密切相关。 此外，携带不表达ATG 10的肿瘤的患者的5年无病生存率和总生存率均显著高于携带表达ATG 10的肿瘤的患者（p = 0.012）。 大肠癌组织中ATG 10表达增加与淋巴管浸润和淋巴结转移有关，提示ATG 10可能是大肠癌潜在的预后指标。
Autophagy has paradoxical and complex functions in cancer development, and autophagy-related genes (ATG) are key regulators in autophagy. Until now, more than 30 different ATG proteins have been identified in yeast, and their mammalian counterparts also have been reported. Although the roles of a few ATG proteins in cancer have been characterized, the role of ATG10 is almost completely unknown. To investigate the clinicopathological role of ATG10 in colorectal cancer, we analyzed ATG10 expression in colorectal cancer tissues and cell lines. Protein expression analysis showed that ATG10 is highly increased in colorectal cancer (tissue - 18/37 cases, 48%; cell line –8/12 cell lines, 66%). Immunohistochemical analysis with clinicopathological features indicated a strong association of the up-regulation of ATG10 with tumor lymph node metastasis (p = 0.005) and invasion (p<0.001). Moreover, both 5-year disease free survival and overall survival rates of patients bearing tumors that did not express ATG10 were significantly higher than those of patients bearing ATG10-expressing tumors (p = 0.012). Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis indicating that ATG10 may be a potential prognostic maker in colorectal cancer.
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