Peroxisome proliferator-activated receptor alpha agonist suppresses neovascularization by reducing both vascular endothelial growth factor and angiopoietin-2 in corneal alkali burn.
Peroxisome proliferator-activated receptor alpha agonist suppresses neovascularization by reducing both vascular endothelial growth factor and angiopoietin-2 in corneal alkali burn.
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DOI：
10.1038/s41598-017-18113-3
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发表时间：
2017-12-19
影响因子：
4.6
通讯作者：
Takahashi H
中科院分区：
文献类型：
--
作者：
Arima T;Uchiyama M;Nakano Y;Nagasaka S;Kang D;Shimizu A;Takahashi H
我们使用大鼠角膜碱烧伤模型研究了过氧化物酶体增殖物激活受体α（PPARα）激动剂滴眼液在伤口愈合中的作用。在烧伤角膜滴注选择性PPARα激动剂非诺贝特后，血管内皮细胞中观察到PPARα阳性细胞，角膜基质中PPARα mRNA上调。非诺贝特在早期阶段抑制中性粒细胞和巨噬细胞的表达，在晚期阶段抑制新血管形成和肌成纤维细胞的产生。非诺贝特不仅降低血管内皮生长因子-A的mRNA表达，而且降低血管生成素-1和血管生成素-2的mRNA表达。此外，非诺贝特通过减少III型胶原蛋白的表达来抑制瘢痕形成。这些数据表明，PPARα激动剂滴眼液可能是治疗角膜伤口的一种新策略，不仅具有抗炎作用，还可预防新生血管形成。
We investigated the effect of a peroxisome proliferator-activated receptor alpha (PPARα) agonist ophthalmic solution in wound healing using a rat corneal alkali burn model. After instillation of a selective agonist of PPARα, fenofibrate, onto the burned cornea, PPARα-positive cells were observed in vascular endothelial cells, and there was upregulation of mRNA of PPARα in corneal stroma. Fenofibrate suppressed expression of neutrophils and macrophages during the early phase, and development of neovascularization and myofibroblast generation during the late phase. Fenofibrate reduced not only mRNA expression of vascular endothelial growth factor-A but also angiopoietin-1 and angiopoietin-2. Furthermore, fenofibrate suppressed scar formation by reducing type III collagen expression. These data suggest that a PPARα agonist ophthalmic solution might be a new strategy for treating corneal wounds through not only anti-inflammatory effects but also by preventing neovascularization.
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影响因子：
--
作者：
Inaga, Sumire;Hirashima, Sayuri;Naguro, Tomonori
通讯作者：
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影响因子：
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影响因子：
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DOI：
10.1097/01.asn.0000076078.50889.43
发表时间：
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影响因子：
13.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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