Regulation of corneal stroma extracellular matrix assembly.
Regulation of corneal stroma extracellular matrix assembly.
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DOI：
10.1016/j.exer.2014.08.001
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发表时间：
2015-04
影响因子：
3.4
通讯作者：
Birk, David E.
中科院分区：
文献类型：
--
作者：
Chen, Shoujun;Mienaltowski, Michael J.;Birk, David E.
关键词：
透明角膜是眼睛的主要屈光元件。基质细胞外基质的精细控制组装对于角膜功能以及建立维持角膜形状和曲率所需的适当机械稳定性至关重要。在基质中，均匀、小直径的胶原纤维，规则地填充有高度有序的分层组织，对于功能至关重要。本综述重点关注角膜基质组装和胶原纤维生成的调节。角膜胶原纤维形成涉及多个分子在连续步骤中相互作用，以及角膜细胞和基质基质成分之间的相互作用。基质具有体内最高的胶原蛋白 V:I 比例。 V 型胶原蛋白调节原纤维组装的成核，从而控制基质中原纤维的数量和较小直径原纤维的组装。角膜基质还富含富含亮氨酸的小蛋白聚糖（SLRP），它们以时间和空间的方式配合调节线性和横向胶原纤维的生长。此外，原纤维相关胶原蛋白 (FACIT)，例如胶原蛋白 XII 和胶原蛋白 XIV，在调节原纤维堆积和层间相互作用中发挥作用。沟通的角膜细胞网络通过创建控制基质基质组装顺序步骤的微域，有助于基质细胞外基质组装的整体和远程调节。角膜细胞控制细胞外基质成分的合成，细胞外基质成分与角膜细胞动态相互作用，以将调节步骤协调成一个内聚过程。基质调节分子的突变或缺陷导致相互作用改变以及透明度和屈光度的缺陷，导致角膜基质病理学，例如基质营养不良、平面角膜和圆锥角膜。
The transparent cornea is the major refractive element of the eye. A finely controlled assembly of the stromal extracellular matrix is critical to corneal function, as well as in establishing the appropriate mechanical stability required to maintain corneal shape and curvature. In the stroma, homogeneous, small diameter collagen fibrils, regularly packed with a highly ordered hierarchical organization, are essential for function. This review focuses on corneal stroma assembly and the regulation of collagen fibrillogenesis. Corneal collagen fibrillogenesis involves multiple molecules interacting in sequential steps, as well as interactions between keratocytes and stroma matrix components. The stroma has the highest collagen V:I ratio in the body. Collagen V regulates the nucleation of protofibril assembly, thus controlling the number of fibrils and assembly of smaller diameter fibrils in the stroma. The corneal stroma is also enriched in small leucine-rich proteoglycans (SLRPs) that cooperate in a temporal and spatial manner to regulate linear and lateral collagen fibril growth. In addition, the fibril-associated collagens (FACITs) such as collagen XII and collagen XIV have roles in the regulation of fibril packing and inter-lamellar interactions. A communicating keratocyte network contributes to the overall and long-range regulation of stromal extracellular matrix assembly, by creating micro-domains where the sequential steps in stromal matrix assembly are controlled. Keratocytes control the synthesis of extracellular matrix components, which interact with the keratocytes dynamically to coordinate the regulatory steps into a cohesive process. Mutations or deficiencies in stromal regulatory molecules result in altered interactions and deficiencies in both transparency and refraction, leading to corneal stroma pathobiology such as stromal dystrophies, cornea plana and keratoconus.
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影响因子：
2.5
作者：
BIRK, DE;NURMINSKAYA, MV;ZYCBAND, EI
通讯作者：
ZYCBAND, EI
DOI：
10.1073/pnas.86.12.4549
发表时间：
1989-06-01
影响因子：
11.1
作者：
BIRK, DE;ZYCBAND, EI;TRELSTAD, RL
通讯作者：
TRELSTAD, RL
影响因子：
2.1
作者：
Banos, Charles C.;Thomas, Amelia H.;Kuo, Catherine K.
通讯作者：
Kuo, Catherine K.
DOI：
10.1111/j.1749-6632.1985.tb51173.x
发表时间：
1985-12-30
影响因子：
5.2
作者：
BIRK, DE;TRELSTAD, RL
通讯作者：
TRELSTAD, RL
影响因子：
4.4
作者：
Beecher, N;Carlson, C;Quantock, AJ
通讯作者：
Quantock, AJ