The Emerging Role of Cell Transdifferentiation in Skeletal Development and Diseases.
The Emerging Role of Cell Transdifferentiation in Skeletal Development and Diseases.
复制标题
细胞转分化在骨骼发育和疾病中的新兴作用。
DOI：
10.3390/ijms23115974
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发表时间：
2022-05-26
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
已知脊椎动物肌肉骨骼系统是由间充质干细胞凝聚成组织成分，然后分化成软骨、骨、肌腱/韧带和肌肉细胞而形成的。这些谱系定向细胞成熟为终末期分化细胞，如肥大软骨细胞和骨细胞，其预期将到期并被由相同谱系途径产生的新分化细胞取代。然而，有新的证据表明细胞转分化在骨发育和疾病中的作用。虽然细胞转分化的概念并不新鲜，但细胞谱系追踪的突破使科学家能够在体内追踪细胞命运。利用这个强大的工具，新的理论已经建立：（1）肥大的软骨细胞可以在软骨内骨形成，骨折修复和一些骨骼疾病中转分化为骨细胞，（2）肌腱细胞，超出了它们在关节运动中的传统作用，直接参与正常骨和软骨形成以及异位骨化。这篇综述的目的是为了更好地了解细胞转分化在骨骼发育和疾病中的关键作用。我们将首先回顾软骨内骨形成过程中软骨细胞向骨细胞的转分化。具体来说，我们将包括在骨形成过程中软骨细胞的命运的辩论的历史，近年来获得的关键发现的关键因素和分子，调节这种细胞命运的变化，以及软骨细胞转分化在骨骼创伤和疾病的作用。此外，我们还将总结肌腱细胞和脂肪细胞在骨骼形成和疾病中的新作用的最新发现。
The vertebrate musculoskeletal system is known to be formed by mesenchymal stem cells condensing into tissue elements, which then differentiate into cartilage, bone, tendon/ligament, and muscle cells. These lineage-committed cells mature into end-stage differentiated cells, like hypertrophic chondrocytes and osteocytes, which are expected to expire and to be replaced by newly differentiated cells arising from the same lineage pathway. However, there is emerging evidence of the role of cell transdifferentiation in bone development and disease. Although the concept of cell transdifferentiation is not new, a breakthrough in cell lineage tracing allowed scientists to trace cell fates in vivo. Using this powerful tool, new theories have been established: (1) hypertrophic chondrocytes can transdifferentiate into bone cells during endochondral bone formation, fracture repair, and some bone diseases, and (2) tendon cells, beyond their conventional role in joint movement, directly participate in normal bone and cartilage formation, and ectopic ossification. The goal of this review is to obtain a better understanding of the key roles of cell transdifferentiation in skeletal development and diseases. We will first review the transdifferentiation of chondrocytes to bone cells during endochondral bone formation. Specifically, we will include the history of the debate on the fate of chondrocytes during bone formation, the key findings obtained in recent years on the critical factors and molecules that regulate this cell fate change, and the role of chondrocyte transdifferentiation in skeletal trauma and diseases. In addition, we will also summarize the latest discoveries on the novel roles of tendon cells and adipocytes on skeletal formation and diseases.
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影响因子：
4.6
作者：
Aghajanian P;Xing W;Cheng S;Mohan S
通讯作者：
Mohan S
DOI：
10.1002/jbmr.1639
发表时间：
2012-08
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Dao DY;Jonason JH;Zhang Y;Hsu W;Chen D;Hilton MJ;O'Keefe RJ
通讯作者：
O'Keefe RJ
影响因子：
11.8
作者：
Day, TF;Guo, XZ;Yang, YZ
通讯作者：
Yang, YZ
DOI：
10.1242/dev.137489
发表时间：
2016-10-15
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Houben A;Kostanova-Poliakova D;Weissenböck M;Graf J;Teufel S;von der Mark K;Hartmann C
通讯作者：
Hartmann C
影响因子：
11.8
作者：
Blitz, Einat;Viukov, Sergey;Sharir, Amnon;Shwartz, Yulia;Galloway, Jenna L.;Pryce, Brian A.;Johnson, Randy L.;Tabin, Clifford J.;Schweitzer, Ronen;Zelzer, Elazar
通讯作者：
Zelzer, Elazar