Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind.
Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind.
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DOI：
10.1016/j.neuron.2010.09.021
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发表时间：
2010-10-06
期刊：
影响因子：
16.2
通讯作者：
Rauschecker, Josef P.
中科院分区：
文献类型：
--
作者：
Renier, Laurent A.;Anurova, Irina;De Volder, Anne G.;Carlson, Synnove;VanMeter, John;Rauschecker, Josef P.
早期失明人类的枕叶皮层（OC）在各种非视觉感知和认知任务中被激活，但对其模块化组织知之甚少。使用功能性 MRI，我们测试了早期盲人的 OC 中听觉与触觉、空间与非空间信息的处理是否分离。没有观察到模态特异性 OC 激活。然而，右枕中回（MOG）对听觉和触觉刺激的空间处理表现出优于非空间处理的偏好。此外，MOG 活动与个体声音定位性能的准确性相关。在视力正常的对照组中，大多数纹外 OC（包括 MOG）在听觉和触觉条件下被停用，但右侧 MOG 在空间任务中比非空间视觉任务更被激活。因此，尽管盲人重组后的 OC 中驱动神经元的感觉方式发生了改变，但无论视觉体验如何，纹状外皮层的功能特化仍然保留。
The occipital cortex (OC) of early-blind humans is activated during various nonvisual perceptual and cognitive tasks, but little is known about its modular organization. Using functional MRI we tested whether processing of auditory versus tactile and spatial versus nonspatial information was dissociated in the OC of the early blind. No modality-specific OC activation was observed. However, the right middle occipital gyrus (MOG) showed a preference for spatial over nonspatial processing of both auditory and tactile stimuli. Furthermore, MOG activity was correlated with accuracy of individual sound localization performance. In sighted controls, most of extrastriate OC, including the MOG, was de-activated during auditory and tactile conditions, but the right MOG was more activated during spatial than nonspatial visual tasks. Thus, although the sensory modalities driving the neurons in the reorganized OC of blind individuals are altered, the functional specialization of extrastriate cortex is retained regardless of visual experience.
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影响因子：
3.7
作者：
Collignon, Olivier;Lassonde, Maryse;Veraart, Claude
通讯作者：
Veraart, Claude
影响因子：
4.8
作者：
Burton, H;Sinclair, RJ;McLaren, DG
通讯作者：
McLaren, DG
影响因子：
64.8
作者：
Cohen, LG;Celnik, P;Hallett, M
通讯作者：
Hallett, M
DOI：
10.1073/pnas.88.5.1621
发表时间：
1991-03-01
影响因子：
11.1
作者：
HAXBY, JV;GRADY, CL;RAPOPORT, SI
通讯作者：
RAPOPORT, SI
影响因子：
2.5
作者：
HYVARINEN, J;CARLSON, S;HYVARINEN, L
通讯作者：
HYVARINEN, L