Progress in Stem Cell Therapy for Spinal Cord Injury.
Progress in Stem Cell Therapy for Spinal Cord Injury.
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DOI：
10.1155/2020/2853650
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发表时间：
2020
影响因子：
4.3
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Gao L;Peng Y;Xu W;He P;Li T;Lu X;Chen G
脊髓损伤（Spinal cord injury，SCI）是一种严重的神经系统疾病，好发于青少年，致残率高。然而，目前仍缺乏有效的治疗方法，干细胞治疗脊髓损伤已逐渐成为一个新的研究热点。本文就脊髓损伤SC治疗的研究进展作一综述。 回顾文献，总结不同SC类型和联合SC治疗SCI的新方法的疗效、策略、相关机制、安全性和临床应用。 大量的研究集中在脊髓损伤的SC治疗上，其中大多数显示出良好的效果。用于SCI治疗的常见SC类型包括间充质干细胞（MSC）、造血干细胞（HSC）、神经干细胞（NSC）、诱导多能干细胞（iPSC）和胚胎干细胞（ESC）。治疗模式包括体内和体外诱导。移植途径包括静脉内、经动脉、经鼻、腹膜内、鞘内和髓内注射。大多数SCI的SC治疗使用的细胞数量从数万到数百万不等。早期或晚期SC给药，是否应用免疫抑制剂仍有争议。SC治疗的潜在机制包括组织修复和替代、神经营养、再生和促进血管生成、抗凋亡和抗炎。常见的安全问题包括血栓形成和栓塞、致瘤性和不稳定性、感染、高烧，甚至死亡。最近，一些新的方法也被开发出来，例如内源性SC的药理学激活、生物材料、3D打印和光遗传学，大大提高了SC治疗SCI的应用。 大多数研究支持SC治疗对SCI的影响，而少数研究不支持。SCI SC治疗的细胞类型、机制和策略在不同研究中有很大差异。此外，安全性也不容忽视，需要更多的临床试验。新技术的应用将促进脊髓损伤的SC治疗。
Spinal cord injury (SCI) is one of the serious neurological diseases that occur in young people with high morbidity and disability. However, there is still a lack of effective treatments for it. Stem cell (SC) treatment of SCI has gradually become a new research hotspot over the past decades. This article is aimed at reviewing the research progress of SC therapy for SCI. Review the literature and summarize the effects, strategies, related mechanisms, safety, and clinical application of different SC types and new approaches in combination with SC in SCI treatment. A large number of studies have focused on SC therapy for SCI, most of which showed good effects. The common SC types for SCI treatment include mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs). The modes of treatment include in vivo and in vitro induction. The pathways of transplantation consist of intravenous, transarterial, nasal, intraperitoneal, intrathecal, and intramedullary injections. Most of the SC treatments for SCI use a number of cells ranging from tens of thousands to millions. Early or late SC administration, application of immunosuppressant or not are still controversies. Potential mechanisms of SC therapy include tissue repair and replacement, neurotrophy, and regeneration and promotion of angiogenesis, antiapoptosis, and anti-inflammatory. Common safety issues include thrombosis and embolism, tumorigenicity and instability, infection, high fever, and even death. Recently, some new approaches, such as the pharmacological activation of endogenous SCs, biomaterials, 3D print, and optogenetics, have been also developed, which greatly improved the application of SC therapy for SCI. Most studies support the effects of SC therapy on SCI, while a few studies do not. The cell types, mechanisms, and strategies of SC therapy for SCI are very different among studies. In addition, the safety cannot be ignored, and more clinical trials are required. The application of new technology will promote SC therapy of SCI.
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影响因子：
7.5
作者：
Amemori T;Ruzicka J;Romanyuk N;Jhanwar-Uniyal M;Sykova E;Jendelova P
通讯作者：
Jendelova P
人类诱导多能干细胞的脊髓损伤的早期干预。
影响因子：
3.7
作者：
All AH;Gharibani P;Gupta S;Bazley FA;Pashai N;Chou BK;Shah S;Resar LM;Cheng L;Gearhart JD;Kerr CL
通讯作者：
Kerr CL
影响因子：
5.6
作者：
Cheng Z;Zhu W;Cao K;Wu F;Li J;Wang G;Li H;Lu M;Ren Y;He X
通讯作者：
He X
DOI：
10.1093/brain/awr339
发表时间：
2012-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Cusimano M;Biziato D;Brambilla E;Donegà M;Alfaro-Cervello C;Snider S;Salani G;Pucci F;Comi G;Garcia-Verdugo JM;De Palma M;Martino G;Pluchino S
通讯作者：
Pluchino S
影响因子：
2.7
作者：
BAIN, G;KITCHENS, D;GOTTLIEB, DI
通讯作者：
GOTTLIEB, DI