Impact of COVID-19 on mental illness in vaccinated and unvaccinated people: a population-based cohort study in OpenSAFELY
Impact of COVID-19 on mental illness in vaccinated and unvaccinated people: a population-based cohort study in OpenSAFELY
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COVID-19 对接种疫苗和未接种疫苗人群的精神疾病的影响：OpenSAFELY 中基于人群的队列研究
DOI：
10.1101/2023.12.06.23299602
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Walker V
中科院分区：
文献类型：
--
作者：
Walker V
背景COVID-19与随后的精神疾病在医院和人群为基础的研究。关于COVID-19疫苗接种对COVID-19精神健康后果影响的证据有限。方法在英国国民保健服务的批准下，我们使用了链接的电子健康记录（OpenSAFELY-TPP）在“接种前”队列中进行分析（17，619，987人）在野生型/α变体时代进行了随访（2020年1月至2021年6月），以及Delta变异时代（2021年6月至12月）的“接种疫苗”和“未接种疫苗”队列（分别为13，716，225人和3，130，581人）。我们估计了调整后的风险比（aHR），将诊断为COVID-19后的精神疾病发病率与诊断为COVID-19前或未诊断为COVID-19时的发病率进行比较。结果我们考虑了8种结果：抑郁症、严重精神疾病、广泛性焦虑、创伤后应激障碍、进食障碍、成瘾、自残和自杀。在每个队列中，与COVID-19之前或没有COVID-19相比，大多数结局的发生率在COVID-19诊断后1-4周内升高。接种疫苗减轻了COVID-19对心理健康的不利影响：在COVID-19后1-4周内，抑郁症和严重精神疾病的aHR（95% CI）为1.93（1.88-1.98）和1.42（1.24-1.61）分别在接种前队列和1.79（1.68-1.91）和2.21（1.99-2.45），相比之下，接种组分别为1.16（1.12-1.20）和0.91（0.84-0.98）。住院后的发病率高于非住院COVID-19，且持续时间更长。解释在未接种疫苗的人中，严重COVID-19后精神疾病的发病率升高长达一年。接种疫苗减轻COVID-19对心理健康的不利影响。资助医学研究理事会（MC_PC_20059）和NIHR（COV-LT-0009）。
BackgroundCOVID-19 is associated with subsequent mental illness in both hospital- and population-based studies. Evidence regarding effects of COVID-19 vaccination on mental health consequences of COVID-19 is limited.MethodsWith the approval of NHS England, we used linked electronic health records (OpenSAFELY-TPP) to conduct analyses in a ‘pre-vaccination’ cohort (17,619,987 people) followed during the wild-type/Alpha variant eras (January 2020-June 2021), and ‘vaccinated’ and ‘unvaccinated’ cohorts (13,716,225 and 3,130,581 people respectively) during the Delta variant era (June-December 2021). We estimated adjusted hazard ratios (aHRs) comparing the incidence of mental illness after diagnosis of COVID-19 with the incidence before or without COVID-19.OutcomesWe considered eight outcomes: depression, serious mental illness, general anxiety, post-traumatic stress disorder, eating disorders, addiction, self-harm, and suicide. Incidence of most outcomes was elevated during weeks 1-4 after COVID-19 diagnosis, compared with before or without COVID-19, in each cohort. Vaccination mitigated the adverse effects of COVID-19 on mental health: aHRs (95% CIs) for depression and for serious mental illness during weeks 1-4 after COVID-19 were 1.93 (1.88-1.98) and 1.42 (1.24-1.61) respectively in the pre-vaccination cohort and 1.79 (1.68-1.91) and 2.21 (1.99-2.45) respectively in the unvaccinated cohort, compared with 1.16 (1.12-1.20) and 0.91 (0.84-0.98) respectively in the vaccinated cohort. Elevation in incidence was higher, and persisted for longer, after hospitalised than non-hospitalised COVID-19.InterpretationIncidence of mental illness is elevated for up to a year following severe COVID-19 in unvaccinated people. Vaccination mitigates the adverse effect of COVID-19 on mental health.FundingMedical Research Council (MC_PC_20059) and NIHR (COV-LT-0009).
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影响因子：
15.8
作者：
Taquet M;Dercon Q;Luciano S;Geddes JR;Husain M;Harrison PJ
通讯作者：
Harrison PJ
DOI：
10.1136/jnnp-2021-327565
发表时间：
2021-12
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Klaser K;Thompson EJ;Nguyen LH;Sudre CH;Antonelli M;Murray B;Canas LS;Molteni E;Graham MS;Kerfoot E;Chen L;Deng J;May A;Hu C;Guest A;Selvachandran S;Drew DA;Modat M;Chan AT;Wolf J;Spector TD;Hammers A;Duncan EL;Ourselin S;Steves CJ
通讯作者：
Steves CJ
影响因子：
13.8
作者：
Abel KM;Carr MJ;Ashcroft DM;Chalder T;Chew-Graham CA;Hope H;Kapur N;McManus S;Steeg S;Webb RT;Pierce M
通讯作者：
Pierce M
疑似 COVID-19 感染者的心理困扰：英国家庭纵向研究分析
影响因子：
5.4
作者：
C. Niedzwiedz;M. Benzeval;Kirsten J Hainey;A. Leyland;S. Katikireddi
通讯作者：
S. Katikireddi
影响因子：
120.7
作者：
Tenforde, Mark W.;Self, Wesley H.;Patel, Manish M.
通讯作者：
Patel, Manish M.