Anxiety and depression symptoms after COVID-19 infection: results from the COVID Symptom Study app.
Anxiety and depression symptoms after COVID-19 infection: results from the COVID Symptom Study app.
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DOI：
10.1136/jnnp-2021-327565
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Steves CJ
中科院分区：
文献类型：
--
作者：
Klaser K;Thompson EJ;Nguyen LH;Sudre CH;Antonelli M;Murray B;Canas LS;Molteni E;Graham MS;Kerfoot E;Chen L;Deng J;May A;Hu C;Guest A;Selvachandran S;Drew DA;Modat M;Chan AT;Wolf J;Spector TD;Hammers A;Duncan EL;Ourselin S;Steves CJ
据报道，SARS-CoV-2感染后出现了心理健康问题。然而，没有对未感染的个人的患病率和共同危险因素(例如肥胖、共病)的影响进行比较。我们在大型社区冠状病毒症状研究中确定了新冠肺炎与精神健康的关系。我们使用两份有效的问卷评估了2021年2月至4月期间413,148人的焦虑和抑郁症状；26,998人的SARS-CoV-2检测呈阳性。我们根据大流行前的身体和精神合并症、BMI、年龄和性别进行了调整。总体而言，26.4%的参与者符合普遍焦虑和抑郁的筛查标准。焦虑和抑郁在以前SARS-CoV-2阳性(30.4%)和阴性(26.1%)的个体中略高一些。与不健康的体重指数和其他并发症的影响相比，这种关联很小，在较年轻的参与者中并不明显(≤40岁)。这些发现对多重敏感性分析是稳健的。SARS-CoV-2感染与焦虑和抑郁之间的相关性在近期(30天)与较远(>；120天)感染的个体中更强，这表明了短期效果。SARS-CoV-2感染与焦虑和抑郁症状之间存在小的关联。符合自我报告的焦虑和抑郁障碍标准的比例仅略高于大流行前。Zoe有限公司，国家健康研究所，慢性病研究基金会，国家卫生研究院，英国医学研究理事会
Mental health issues have been reported after SARS-CoV-2 infection. However, comparison to prevalence in uninfected individuals and contribution from common risk factors (e.g., obesity, comorbidities) have not been examined. We identified how COVID-19 relates to mental health in the large community-based COVID Symptom Study. We assessed anxiety and depression symptoms using two validated questionnaires in 413,148 individuals between February and April 2021; 26,998 had tested positive for SARS-CoV-2. We adjusted for physical and mental pre-pandemic comorbidities, BMI, age, and sex. Overall, 26.4% of participants met screening criteria for general anxiety and depression. Anxiety and depression were slightly more prevalent in previously SARS-CoV-2 positive (30.4%) vs. negative (26.1%) individuals. This association was small compared to the effect of an unhealthy BMI and the presence of other comorbidities, and not evident in younger participants (≤40 years). Findings were robust to multiple sensitivity analyses. Association between SARS-CoV-2 infection and anxiety and depression was stronger in individuals with recent (<30 days) vs. more distant (>120 days) infection, suggesting a short-term effect. A small association was identified between SARS-CoV-2 infection and anxiety and depression symptoms. The proportion meeting criteria for self-reported anxiety and depression disorders is only slightly higher than pre-pandemic. Zoe Limited, National Institute for Health Research, Chronic Disease Research Foundation, National Institutes of Health, Medical Research Council UK
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DOI：
10.1038/s41577-020-00458-y
发表时间：
2020-11
期刊：
Nature reviews. Immunology
影响因子：
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作者：
Kreye J;Reincke SM;Prüss H
通讯作者：
Prüss H
影响因子：
38.1
作者：
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通讯作者：
Padovani, Alessandro
DOI：
10.1192/bjp.2020.212
发表时间：
2021-06
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
O'Connor RC;Wetherall K;Cleare S;McClelland H;Melson AJ;Niedzwiedz CL;O'Carroll RE;O'Connor DB;Platt S;Scowcroft E;Watson B;Zortea T;Ferguson E;Robb KA
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Robb KA
DOI：
10.1016/s2215-0366(20)30462-4
发表时间：
2021-03
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Taquet M;Luciano S;Geddes JR;Harrison PJ
通讯作者：
Harrison PJ
影响因子：
15.1
作者：
Raman B;Cassar MP;Tunnicliffe EM;Filippini N;Griffanti L;Alfaro-Almagro F;Okell T;Sheerin F;Xie C;Mahmod M;Mózes FE;Lewandowski AJ;Ohuma EO;Holdsworth D;Lamlum H;Woodman MJ;Krasopoulos C;Mills R;McConnell FAK;Wang C;Arthofer C;Lange FJ;Andersson J;Jenkinson M;Antoniades C;Channon KM;Shanmuganathan M;Ferreira VM;Piechnik SK;Klenerman P;Brightling C;Talbot NP;Petousi N;Rahman NM;Ho LP;Saunders K;Geddes JR;Harrison PJ;Pattinson K;Rowland MJ;Angus BJ;Gleeson F;Pavlides M;Koychev I;Miller KL;Mackay C;Jezzard P;Smith SM;Neubauer S
通讯作者：
Neubauer S