Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa.
Resting state functional connectivity of networks associated with reward and habit in anorexia nervosa.
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DOI：
10.1002/hbm.24402
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发表时间：
2019-02-01
影响因子：
4.8
通讯作者：
Camchong J
中科院分区：
文献类型：
--
作者：
Haynos AF;Hall LMJ;Lavender JM;Peterson CB;Crow SJ;Klimes-Dougan B;Cullen KR;Lim KO;Camchong J
与奖励和/或习惯学习相关的神经生物学障碍被理论化为维持神经性厌食症（AN）的症状。尽管研究已经调查了与奖励和习惯相关的大脑区域对特定于疾病的线索的反应（例如，食物）和假定的奖励（例如，钱），很少有人知道这些结构背后的电路独立于刺激的功能组织。本研究旨在通过比较AN和健康对照（HC）参与者在这些回路中的静息状态功能连接（RSFC）模式，并描述这些模式与症状的关系，提供AN中与奖励和习惯相关的网络同步性的初始数据。使用在背侧尾状核（NAcc）、腹侧尾状核和背侧尾状核中的理论上选择的种子，反映了从奖励导向区域到习惯导向区域的连续体，在AN限制亚型（n = 19）和HC（n = 19）参与者之间比较RSFC模式（簇阈值：p < .01）.探索RSFC z评分与进食障碍检查（EDE）评分、BMI和疾病持续时间之间的相关性。AN组表现出较低的RSFC之间的NAcc和上级额回，腹侧尾状核和额叶和后部区域之间，背侧尾状核和额叶，颞叶和后部区域之间。在AN组中，较低的NAcc-上级额回RSFC与较高的EDE总体评分相关（r =-0.58，CI：-0.83，-0.13）。这些静息状态的腹侧和背侧额纹状体电路的同步中断，在更广泛的文献背景下考虑，支持进一步调查可能的奖励和习惯障碍支持AN症状的效用。
Neurobiological disturbances associated with reward and/or habit learning are theorized to maintain symptoms of anorexia nervosa (AN). Although research has investigated responses in brain regions associated with reward and habit to disorder-specific cues (e.g., food) and presumed rewards (e.g., money), little is known about the functional organization of the circuits underlying these constructs independent of stimulus. This study aimed to provide initial data on the synchrony of networks associated with reward and habit in AN by comparing resting-state functional connectivity (RSFC) patterns between AN and healthy control (HC) participants in these circuits and delineating how these patterns relate to symptoms. Using theoretically selected seeds in the nucleus accumbens (NAcc), ventral caudate, and dorsal caudate, reflecting a continuum from reward- to habit- oriented regions, RSFC patterns were compared between AN restricting subtype (n = 19) and HC (n = 19) participants (cluster threshold: p < .01). Exploratory correlations between RSFC z-scores and Eating Disorder Examination (EDE) scores, BMI, and illness duration were conducted. The AN group demonstrated lower RSFC between the NAcc and superior frontal gyrus, between the ventral caudate and frontal and posterior regions, and between the dorsal caudate and frontal, temporal, and posterior regions. In the AN group, lower NAcc- superior frontal gyrus RSFC correlated with greater EDE Global scores (r = −.58, CI: −.83, −.13). These resting-state synchrony disruptions of the ventral and dorsal frontostriatal circuits, considered in context of the broader literature, support the utility of further investigating possible reward and habit disturbances supporting symptoms in AN.
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