Social network-based group intervention to promote HIV prevention in Uganda: study protocol for a cluster randomized controlled trial of Game Changers.
Social network-based group intervention to promote HIV prevention in Uganda: study protocol for a cluster randomized controlled trial of Game Changers.
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基于社会网络的群体干预促进乌干达艾滋病毒预防：游戏规则改变者的整群随机对照试验的研究方案。
DOI：
10.1186/s13063-022-06186-z
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发表时间：
2022-03-28
期刊：
影响因子：
2.5
通讯作者：
Okoboi S
中科院分区：
文献类型：
--
作者：
Wagner GJ;Bogart LM;Green HD;Storholm ED;Klein DJ;McBain RK;Serunkuuma R;Mubiru K;Matovu JKB;Okoboi S
需要采取创新战略，在各社区有效传播艾滋病毒预防信息，并在促进艾滋病毒预防的同时减少艾滋病毒污名化。这项随机对照试验将评估基于社交网络的团体干预的有效性，游戏改变者，培训艾滋病毒感染者（PLWH）鼓励其社交网络成员在艾滋病毒护理中使用艾滋病毒保护行为PLWH至少1年将被随机分配接受8次团体宣传培训干预或无干预对照组。每名登记的PLWH（索引参与者）将被要求招募最多四名社交网络成员（alter参与者）。将在基线和第6、12和18个月对索引和变更受试者进行评估。主要成果是艾滋病毒检测和安全套的使用改变参与者，次要成果是参与艾滋病毒预防宣传和内化艾滋病毒的耻辱指数参与者。将进行重复测量的多变量回归分析，以比较干预组和对照组之间的结果，以及成本效益评价。这种基于社会网络的艾滋病毒预防方法在生物医学干预措施时代特别及时，因为生物医学干预措施需要将有效的艾滋病毒预防和护理信息广泛渗透到社区。将艾滋病毒感染者作为控制（而不是造成）艾滋病毒流行的解决方案的核心，有可能减少艾滋病毒的耻辱感，并改善个人和网络层面的预防成果。ClinicalTrials.gov NIH临床试验注册NCT 05098015。于2021年10月18日注册。
Innovative strategies are needed to disseminate HIV prevention messages across communities efficiently, as well as reduce HIV stigma while promoting HIV prevention. This randomized controlled trial will evaluate the efficacy of a social network-based group intervention, Game Changers, which trains persons living with HIV (PLWH) to encourage members of their social network to use HIV protective behaviors PLWH in HIV care for at least 1 year will be randomly assigned to receive the 8-session group advocacy training intervention or no-intervention control group. Each enrolled PLWH (index participant) will be asked to recruit up to four social network members (alter participant). Assessments will be administered at baseline and months 6, 12, and 18 to both index and alter participants. The primary outcomes are HIV testing and condom use among alter participants; secondary outcomes are engagement in HIV prevention advocacy and internalized HIV stigma among index participants. Repeated-measures multivariable regression analyses will be conducted to compare outcomes between the intervention and control arms, in addition to a cost-effectiveness evaluation. This social network-based approach to HIV prevention is particularly timely in the era of biomedical interventions, which require widespread penetration of effective HIV prevention and care messaging into communities. Positioning PLWH as central to the solution for controlling (vs. causing) the HIV epidemic has the potential to reduce HIV stigma and improve prevention outcomes at the individual and network levels. ClinicalTrials.gov NIH Clinical Trial Registry NCT05098015. Registered on October 18, 2021.
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DOI：
10.1097/qai.0000000000001886
发表时间：
2019-01-01
影响因子：
3.6
作者：
Mustanski, Brian;Morgan, Ethan;Newcomb, Michael E.
通讯作者：
Newcomb, Michael E.
DOI：
10.1016/s0140-6736(15)60095-2
发表时间：
2015-07-11
期刊：
Lancet (London, England)
影响因子：
--
作者：
Kim DA;Hwong AR;Stafford D;Hughes DA;O'Malley AJ;Fowler JH;Christakis NA
通讯作者：
Christakis NA
影响因子：
5.4
作者：
Hedges, Larry V.;Citkowicz, Martyna
通讯作者：
Citkowicz, Martyna
影响因子：
4.2
作者：
Kaponda, Chrissie P. N.;Norr, Kathleen F.;Dancy, Barbara L.
通讯作者：
Dancy, Barbara L.
DOI：
10.1136/bmj.e7586
发表时间：
2013-01-08
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Chan AW;Tetzlaff JM;Gøtzsche PC;Altman DG;Mann H;Berlin JA;Dickersin K;Hróbjartsson A;Schulz KF;Parulekar WR;Krleza-Jeric K;Laupacis A;Moher D
通讯作者：
Moher D