Involvement of Rh blood group polypeptides in the maintenance of aminophospholipid asymmetry.
Involvement of Rh blood group polypeptides in the maintenance of aminophospholipid asymmetry.
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Rh 血型多肽参与维持氨基磷脂不对称性。
DOI：
10.1021/bi00497a003
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Cartron,JP
中科院分区：
文献类型：
--
作者：
Schroit,AJ;Bloy,C;Connor,J;Cartron,JP
Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, and INSERM U76, Institut National de Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France Received August 6, 1990; Revised Manuscript Received September 5, 1990 abstract: The human erythrocyte (RBC) Rh blood group systemconsists of a complex of distinct integral membrane polypeptides with physical properties common to the aminophospholipid transporter responsible for the transbilayer movement of phosphatidylserine (PS) in RBC. To assess the involvement of Rh polypeptides in PS translocation, the aminophospholipid translocase was labeled with a photoactivatable PS analogue, l25I-azido-PS, and with an inhibitor of PS transport, 125I-labeled 2-(2-pyridyldithio) ethylamine. The ability of monoclonal Rh antibodies to immunoprecipitate the labeled transporter was determined. Immunoprecipitated Rh polypeptides were found to be labeled with the aminophospholipid translocase markers, suggesting that Rh proteins are involved in the transbilayer movement of PS.
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