Reduced task-related suppression during semantic repetition priming in schizophrenia.
Reduced task-related suppression during semantic repetition priming in schizophrenia.
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DOI：
10.1016/j.pscychresns.2009.09.005
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发表时间：
2010-02-28
影响因子：
2.3
通讯作者：
Kubicki, Marek
中科院分区：
文献类型：
--
作者：
Jeong, Bumseok;Kubicki, Marek
很少有研究报告精神分裂症默认网络内大脑活动的抑制减少。然而，任务特异性激活与默认网络抑制之间的关系以及这种关系对大脑功能的影响仍不清楚，并且迄今为止尚未在精神分裂症中进行研究。我们使用之前发布的显示精神分裂症语义编码和白质完整性之间关系的数据，并使用独立成分分析（ICA）重新分析数据。十名健康对照受试者和十名慢性精神分裂症患者接受了功能磁共振成像扫描，在此期间他们进行了处理范式的级别。使用张量 ICA 比较两组之间语义处理相关的独立分量。语义重复启动的独立组成部分显示两组之间存在显着差异。该成分由精神分裂症患者大脑内较少激活和较少抑制的区域组成。不太活跃的区域包括双侧额下回和边缘上回。受抑制程度较低的区域包括内侧额回、后扣带回、楔前叶和右侧小脑。我们的结果表明精神分裂症语义重复启动缺陷有两个组成部分。一个与默认网络（主要是楔前叶和内侧额回）的抑制较弱有关，另一个与直接参与语义重复启动的区域的激活较弱有关。
Few studies have reported the reduced suppression of brain activity within the default network in schizophrenia. The relationship, however, between task-specific activation and default network suppression, as well as impact of this relationship on brain function is still not clear, and has not been studied in schizophrenia so far. We used previously published data showing relationship between semantic encoding and white matter integrity in schizophrenia, and reanalyzed the data using independent component analysis (ICA). Ten healthy control subjects and ten chronic schizophrenics underwent an fMRI scan during which they performed Levels of Processing paradigm. The semantic processing related independent components were compared between two groups using tensor ICA. An independent component of semantic repetition priming showed a significant difference between two groups. The component consisted of both less activated and less suppressed regions within the schizophrenics’ brain. The less activated regions included the bilateral inferior frontal gyri and the supramarginal gyri. The less suppressed regions included the medial frontal gyrus, the posterior cingulate gyrus, precuneus and right cerebellum. Our results suggest two components of semantic repetition priming deficit in schizophrenia. One related to weaker suppression of default network, mainly precuneus and medial frontal gyrus, the other related to weaker activation of regions directly involved in semantic repetition priming.
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