Unilateral low-frequency stimulation of central piriform cortex delays seizure development induced by amygdaloid kindling in rats
Unilateral low-frequency stimulation of central piriform cortex delays seizure development induced by amygdaloid kindling in rats
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单侧低频刺激中央梨状皮层可延缓杏仁核点燃引起的大鼠癫痫发作
DOI：
10.1016/j.neuroscience.2005.12.006
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发表时间：
2006-12
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
点燃部位的低频刺激干扰点燃癫痫发生的过程。本研究探讨了低频电刺激大鼠中央梨状皮质对杏仁核点燃诱发癫痫发作的影响。每日1次点燃刺激（60 Hz，150-300 μ A，2s脉冲串，1 ms）后立即给予同侧或对侧中央梨状皮质低频刺激（1Hz，50-150 μ A，0.1ms脉冲串，15 min），共30天。低频刺激同侧或对侧中央梨状皮质显着抑制癫痫发作阶段的进展，并减少后放电持续时间在整个过程中的杏仁核点燃。低频刺激两侧中央梨状皮质引起的显著抑制主要是由于从0期到1期和从3期到4期癫痫发作的进展显著延迟。此外，低频刺激的抑制作用在停止刺激时并没有消失，它可以持续至少10天。这些发现表明，点燃灶以外的脑区，如两侧的中央梨状皮质，也可以作为低频刺激的合理靶点，以延缓杏仁核点燃诱发的癫痫发作的发展。第二，同侧中央梨状皮质一样，对侧中央梨状皮质也可能参与局灶性癫痫发作的进展和继发泛化。本研究提示，单侧低频刺激中央梨状皮质可能具有显著的抗癫痫作用，并可能有助于探索有效和持久的治疗人类颞叶癫痫的方法。
Low-frequency stimulation of the kindling site interferes with the course of kindling epileptogenesis. The present study examined the effect of unilateral low-frequency stimulation of the central piriform cortex on seizure development induced by amygdaloid kindling in rats. The ipsilateral or contralateral central piriform cortex received low-frequency stimulation (15 min train of 0.1 ms pulses at 1Hz and 50–150 μA) immediately after termination of once daily kindling stimulation (2 s train of 1 ms pulses at 60Hz and 150–300 μA) in the right amygdala for 30 days. Low-frequency stimulation of either the ipsilateral or contralateral central piriform cortex significantly suppressed the progression of seizure stages and reduced afterdischarge duration throughout the course of amygdaloid kindling. The marked suppression induced by low-frequency stimulation of the central piriform cortex on either side was predominantly due to the significant retardation of progression from stage 0 to stage 1 and stage 3 to stage 4 seizures. In addition, the suppressive effect of low-frequency stimulation did not disappear when the stimulation was stopped; it could persist for at least 10 days. These findings indicate that brain areas other than the kindling focus, such as the central piriform cortex on both sides, can also be used as reasonable targets for low-frequency stimulation to retard seizure development induced by amygdaloid kindling. Secondly, like the ipsilateral central piriform cortex, the contralateral central piriform cortex may also participate in the progression and secondary generalization of focal seizures. The study suggests that unilateral low-frequency stimulation of the central piriform cortex may have a significant antiepileptogenic effect, and may be helpful for exploring effective and long-lasting therapies for human temporal lobe epilepsy.
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DOI：
10.3758/bf03334555
发表时间：
1980-05
期刊：
Bulletin of the psychonomic society
影响因子：
--
作者：
J. Gaito;S. Gaito
通讯作者：
J. Gaito;S. Gaito
DOI：
10.3758/bf03334511
发表时间：
1980-04
期刊：
Bulletin of the psychonomic society
影响因子：
--
作者：
J. Gaito
通讯作者：
J. Gaito
影响因子：
2.3
作者：
H. Lehmann;U. Ebert;W. Löscher
通讯作者：
H. Lehmann;U. Ebert;W. Löscher
影响因子：
3.3
作者：
Schwabe, K;Ebert, U;Löscher, W
通讯作者：
Löscher, W
DOI：
10.1017/s0317167100023702
发表时间：
1980-02
期刊：
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
影响因子：
--
作者：
J. Gaito
通讯作者：
J. Gaito