The unusual reproductive system of head and body lice (Pediculus humanus).

The unusual reproductive system of head and body lice (Pediculus humanus).
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DOI:
10.1111/mve.12287
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发表时间:
2018-06
影响因子:
1.9
通讯作者:
Ross L
Ross L
中科院分区:
农林科学2区
文献类型:
--
作者:
DE LA Filia AG;Andrewes S;Clark JM;Ross L

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昆虫的繁殖是极其多变的,但替代遗传系统的影响往往被忽视的杀虫剂抗性的进化研究。人虱(Phthiraptera:Pediculidae)的两种生态型,即人头虱和体虱,都是人类体外寄生虫,其控制受到最近抗性等位基因传播的挑战。本研究首次最终确定头虱和体虱都通过父系基因组消除(PGE)繁殖,这是一种不寻常的遗传系统,其中男性只传递其母系衍生的染色体。在这里,我们调查遗传模式的父母基因组使用基因分型方法在两个生态型的家庭,并显示,杂合子男性只或优先通过一个等位基因,而女性都在孟德尔的方式传输。然而,我们确实观察到父体染色体偶尔通过雄性传递,这是已知的第一例全基因组减数分裂驱动不完整的PGE病例。最后,我们讨论了这一发现对耐药性演变的潜在影响,并邀请开发新的理论模型,以了解这些知识如何有助于提高以杀虱剂为基础的管理计划的成功率。
Insect reproduction is extremely variable, but the implications of alternative genetic systems are often overlooked in studies on the evolution of insecticide resistance. Both ecotypes of Pediculus humanus (Phthiraptera: Pediculidae), the human head and body lice, are human ectoparasites, the control of which is challenged by the recent spread of resistance alleles. The present study conclusively establishes for the first time that both head and body lice reproduce through paternal genome elimination (PGE), an unusual genetic system in which males transmit only their maternally derived chromosomes. Here, we investigate inheritance patterns of parental genomes using a genotyping approach across families of both ecotypes and show that heterozygous males exclusively or preferentially pass on one allele only, whereas females transmit both in a Mendelian fashion. We do however observe occasional transmission of paternal chromosomes through males, representing the first known case of PGE in which whole‐genome meiotic drive is incomplete. Finally, we discuss the potential implications of this finding for the evolution of resistance and invite the development of new theoretical models of how this knowledge might contribute to increasing the success of pediculicide‐based management schemes.
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发表时间: 2015-06-01
影响因子: 5.3
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期刊: ENTOMOPHAGA
影响因子: --
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