Mismatch induced speciation in Salmonella: model and data.

Mismatch induced speciation in Salmonella: model and data.
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DOI:
10.1098/rstb.2006.1925
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发表时间:
2006-11-29
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Achtman M
Achtman M
中科院分区:
其他
文献类型:
--
作者:
Falush D;Torpdahl M;Didelot X;Conrad DF;Wilson DJ;Achtman M

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在细菌中,DNA序列错配是远亲生物之间重组的障碍,并可能促进物种的凝聚力。我们进行的计算机模拟表明,一旦超过临界种群规模,重组的同源性依赖可以导致中性进化的种群中的从头物种形成。我们的模型可以解释在沙门氏菌属中观察到的分化和遗传交换的模式,而不需要引用自然选择或地理种群细分。如果该模型得到验证,基于大量的序列数据,将意味着肠沙门氏菌命名的亚种对应于良好的生物种类,从而使物种界限变得客观。然而,使用几种常规工具分析的多位点序列分型数据提供了一种误导性印象,使人对肠杆菌亚种之间的关系产生了误解,并没有提供确定目前是否正在形成新物种的解决方案。
In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations which show that the homology dependence of recombination can cause de novo speciation in a neutrally evolving population once a critical population size has been exceeded. Our model can explain the patterns of divergence and genetic exchange observed in the genus Salmonella, without invoking either natural selection or geographical population subdivision. If this model was validated, based on extensive sequence data, it would imply that the named subspecies of Salmonella enterica correspond to good biological species, making species boundaries objective. However, multilocus sequence typing data, analysed using several conventional tools, provide a misleading impression of relationships within S. enterica subspecies enterica and do not provide the resolution to establish whether new species are presently being formed.
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