The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma.
The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma.
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DOI：
10.3390/biomedicines10112683
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发表时间：
2022-10-24
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
背景资料：磁共振（MR）弛豫测量提供了一种非侵入性的工具，以区分卵巢癌相关性卵巢癌（EAOC）和卵巢腺瘤（OE），具有高准确性。然而，该方法在临床使用中区分恶性肿瘤方面具有局限性，因为R2值取决于设备制造商，并且重复成像是不现实的。目前的研究旨在重新评估MR弛豫测量的诊断准确性，并探讨一个更强大的工具来区分EAOC从OE. Methods：这项回顾性研究是在我们的机构从2012年12月，2022年5月。本研究共纳入150例患者。良性卵巢肿瘤108例主要行腹腔镜手术，可疑恶性肿瘤42例行开腹手术。收集了患者病历的图表审查信息。结果：多因素回归分析显示年龄、肿瘤直径、R2值是独立的恶性预测因素。EAOC和OE的危险性评估算法（e-NARA）指数提供了较高的准确性（敏感性，85.7%;特异性，87.0%）区分EAOC和OE. Conclusions：e-NARA指数是一个可靠的工具，以评估恶性肿瘤的恶性转化的可能性。
Background: Magnetic resonance (MR) relaxometry provides a noninvasive tool to discriminate endometriosis-associated ovarian cancer (EAOC) from ovarian endometrioma (OE) with high accuracy. However, this method has a limitation in discriminating malignancy in clinical use because the R2 value depends on the device manufacturer and repeated imaging is unrealistic. The current study aimed to reassess the diagnostic accuracy of MR relaxometry and investigate a more powerful tool to distinguish EAOC from OE. Methods: This retrospective study was conducted at our institution from December, 2012, to May, 2022. A total of 150 patients were included in this study. Patients with benign ovarian tumors (n = 108) mainly received laparoscopic surgery, and cases with suspected malignancy (n = 42) underwent laparotomy. Information from a chart review of the patients’ medical records was collected. Results: A multiple regression analysis revealed that the age, the tumor diameter, and the R2 value were independent malignant predicting factors. The endometriotic neoplasm algorithm for risk assessment (e-NARA) index provided high accuracy (sensitivity, 85.7%; specificity, 87.0%) to discriminate EAOC from OE. Conclusions: The e-NARA index is a reliable tool to assess the probability of malignant transformation of endometrioma.
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DOI：
10.1097/pas.0b013e3181cf3d79
发表时间：
2010-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kurman RJ;Shih IeM
通讯作者：
Shih IeM
影响因子：
9
作者：
Ishizuka, Mitsuru;Nagata, Hitoshi;Kubota, Keiichi
通讯作者：
Kubota, Keiichi
影响因子：
--
作者：
Koshiyama M;Matsumura N;Konishi I
通讯作者：
Konishi I
影响因子：
6.4
作者：
Darelius, Anna;Kristjansdottir, Bjorg;Strandell, Annika
通讯作者：
Strandell, Annika
影响因子：
8.8
作者：
Kim, H. S.;Kim, T. H.;Chung, H. H.;Song, Y. S.
通讯作者：
Song, Y. S.