Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds.
Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds.
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DOI：
10.1038/s41467-021-22138-8
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发表时间：
2021-03-30
影响因子：
16.6
通讯作者：
Gutruf P
中科院分区：
文献类型：
--
作者：
Ausra J;Munger SJ;Azami A;Burton A;Peralta R;Miller JE;Gutruf P
用于询问中枢和外周神经系统的无线无电池和完全植入式工具已经定量地扩展了研究自由移动的啮齿动物的机械和电路水平行为的能力。这种装置的重量轻和占地面积小使得能够进行完全皮下植入，从而能够在对受试者行为影响最小的情况下进行研究，并在一系列实验范例中产生广泛的应用。虽然这些优势已经在主要以2D移动的啮齿动物中成功证明，但无线和无电池设备的全部潜力可以用于飞行物种，其中使用系留设备进行询问非常困难或不可能。在这里，我们报告了一个无线，无电池和多模式平台，使光遗传学刺激和生理温度记录在一个高度小型化的形状因子用于鸣禽。该系统通过行为引导的主天线设计和先进的能量管理来实现，以确保在整个3D实验领域中稳定的光遗传学刺激和热成像。总的来说，这些设计方法将无线皮下植入式神经调节和传感工具的使用定量地扩展到先前从体内真实的时间实验中排除的物种。需要对飞行物种进行神经调制的研究是困难的，因为需要有线连接来记录实验数据。在这里，Ausra等人提出了一种无线和无电池的设备，该设备在鸣禽中实现了这一点，鸣禽是用于研究声音学习和维持的模式生物。
Wireless battery free and fully implantable tools for the interrogation of the central and peripheral nervous system have quantitatively expanded the capabilities to study mechanistic and circuit level behavior in freely moving rodents. The light weight and small footprint of such devices enables full subdermal implantation that results in the capability to perform studies with minimal impact on subject behavior and yields broad application in a range of experimental paradigms. While these advantages have been successfully proven in rodents that move predominantly in 2D, the full potential of a wireless and battery free device can be harnessed with flying species, where interrogation with tethered devices is very difficult or impossible. Here we report on a wireless, battery free and multimodal platform that enables optogenetic stimulation and physiological temperature recording in a highly miniaturized form factor for use in songbirds. The systems are enabled by behavior guided primary antenna design and advanced energy management to ensure stable optogenetic stimulation and thermography throughout 3D experimental arenas. Collectively, these design approaches quantitatively expand the use of wireless subdermally implantable neuromodulation and sensing tools to species previously excluded from in vivo real time experiments. Studies requiring neural modulation in species that fly are difficult because of the need for wired connections to record experimental data. Here, Ausra et al. present a wireless and battery free device that achieves this in songbirds, model organisms used to study vocal learning and maintenance.
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影响因子：
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作者：
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影响因子：
16.2
作者：
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通讯作者：
Rogers JA