Incidence, gender influence, and neuropsychological predictors of all cause dementia in the Faroe Islands-the Faroese Septuagenarian cohort.
Incidence, gender influence, and neuropsychological predictors of all cause dementia in the Faroe Islands-the Faroese Septuagenarian cohort.
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DOI：
10.1007/s40520-020-01520-4
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发表时间：
2021-01
影响因子：
4
通讯作者：
Petersen MS
中科院分区：
文献类型：
--
作者：
Paul KC;Debes F;Eliasen E;Weihe P;Petersen MS
利用法罗七十多岁的队列，我们旨在描述痴呆症的发病率，并评估神经认知测试预测后续痴呆症诊断的有效性。在这个基于人群的队列中，713 名 70-74 岁、无痴呆的法罗群岛七十多岁老人接受了临床和神经心理学检查。经过 10 年的随访，收集了所有接受认知评估并被诊断患有痴呆症的参与者的信息。假设服从泊松分布，计算发病率并以 95% 置信区间 (CI) 表示。然后，我们进行了判别分析，以确定最好的一组神经心理学测试，以识别那些会患上痴呆症的人。 10 年间，65 名参与者（9.1%）被诊断患有痴呆症，10 年发病率为每 10 万人年 1,063 例（95% CI=825, 1,343）。女性的发病率高于男性（发病率比（IRR）=1.58；95% CI=0.93，2.71）。经过逐步选择，选择了性别和六种神经心理学指标来区分那些会和不会患痴呆症的人。总体而言，该模型能够正确识别 82% 的不会患痴呆症的人（特异性）和 71% 的会患痴呆症的人（敏感性）。这些结果表明，在涵盖广泛认知能力的大量测试中，反映言语和视觉学习和回忆、视觉空间功能、注意力以及长期记忆编码和检索的测试可能有助于识别处于痴呆症症状前阶段的患者。因此，帮助护理人员识别患痴呆症的风险较高的患者，并相应地调整护理管理。
Using the Faroese Septuagenarian cohort, we aimed to describe the incidence of dementia and assess the validity of neurocognitive tests to predict subsequent dementia diagnosis. In this population-based cohort, 713 Faroese septuagenarians aged 70-74 years without dementia, underwent clinical and neuropsychological examinations. After 10-years of follow-up, information was collected on all participants referred for cognitive evaluations and diagnosed with dementia. Incidence rates were calculated and presented with 95% confidence intervals (CIs), assuming a Poisson distribution. We then performed discriminant analysis to determine the best set of neuropsychological tests to identify those who would develop dementia. Over the 10-years, 65 participants (9.1%) were diagnosed with dementia, with a 10-year incidence rate of 1,063 cases per 100,000 person-years (95% CI=825, 1,343). Women had a greater incidence than men (incidence rate ratio (IRR) =1.58; 95% CI=0.93, 2.71). After stepwise selection, gender and six neuropsychological measures were selected to discriminate between those who would and would not develop dementia. Overall, the model was able to correctly identify 82% of those who would not develop dementia (specificity) and 71% of those who would (sensitivity). These results indicate that among a greater number of tests covering a broad range of cognitive abilities, tests reflecting verbal and visual learning and recall, visuospatial function, attention, and encoding into and retrieval from long-term memory may be helpful in identifying patients in the pre-symptomatic phase of dementia. Thus, helping care-givers identify patients at a higher risk of developing dementia and adjusting management of care accordingly.
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影响因子：
14
作者：
Grasset, Leslie;Brayne, Carol;Helmer, Catherine
通讯作者：
Helmer, Catherine
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H
影响因子：
2.4
作者：
Katsumata, Yuriko;Mathews, Melissa;Fardo, David W.
通讯作者：
Fardo, David W.
影响因子：
4.4
作者：
Petersen, Maria Skaalum;Debes, Frodi;Weihe, Pal
通讯作者：
Weihe, Pal
影响因子：
4
作者：
Petersen, Maria Skaalum;Restorff, Marjun;Joensen, Sofus
通讯作者：
Joensen, Sofus