Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in Alcohol Use Disorder: a randomized trial.
Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in Alcohol Use Disorder: a randomized trial.
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纳曲酮在降低酒精使用障碍中饮酒中的表观遗传主持人：一项随机试验。
DOI：
10.1038/s41397-021-00250-8
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Anton RF
中科院分区：
文献类型：
--
作者：
Schacht JP;Hoffman M;Chen BH;Anton RF
Polymorphisms in genes associated with opioid signaling and dopamine reuptake and inactivation may moderate naltrexone efficacy in Alcohol Use Disorder (AUD), but the effects of epigenetic modification of these genes on naltrexone response are largely unexplored. This study tested interactions between methylation in the μ-opioid receptor (OPRM1), dopamine transporter (SLC6A3), and catechol-O-methyltransferase (COMT) genes as predictors of naltrexone effects on heavy drinking in a 16-week randomized, placebo-controlled trial among 145 treatment-seeking AUD patients. OPRM1 methylation interacted with both SLC6A3 and COMT methylation to moderate naltrexone efficacy, such that naltrexone-treated individuals with lower methylation of the OPRM1 promoter and the SLC6A3 promoter (p=.006), COMT promoter (p=.005), or SLC6A3 3’ untranslated region (p=.004), relative to placebo and to those with higher OPRM1 and SLC6A3 or COMT methylation, had significantly fewer heavy drinking days. Epigenetic modification of opioid- and dopamine-related genes may represent a novel pharmacoepigenetic predictor of naltrexone efficacy in AUD.
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DOI：
10.1111/acer.14431
发表时间：
2020-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Anton RF;Voronin KE;Book SW;Latham PK;Randall PK;Glen WB;Hoffman M;Schacht JP
通讯作者：
Schacht JP
影响因子：
3.3
作者：
Matsumoto, M;Weickert, CS;Weinberger, DR
通讯作者：
Weinberger, DR
通过未翻译基因区域和其他非编码元件调节真核基因表达。
影响因子：
8
作者：
Barrett, Lucy W.;Fletcher, Sue;Wilton, Steve D.
通讯作者：
Wilton, Steve D.
影响因子：
12.3
作者：
Horvath S
通讯作者：
Horvath S
影响因子：
5.8
作者：
Aryee, Martin J.;Jaffe, Andrew E.;Irizarry, Rafael A.
通讯作者：
Irizarry, Rafael A.