Disentangling the functional consequences of the connectivity between optic-flow processing neurons

Disentangling the functional consequences of the connectivity between optic-flow processing neurons
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解开光流处理神经元之间连接的功能后果

DOI:
10.1038/nn.3044
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发表时间:
2012
影响因子:
25
通讯作者:
Borst A
Borst A
中科院分区:
医学1区
文献类型:
--
作者:
Weber F;Machens CK;Borst A

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通常,感觉区域的神经元是高度互连的。耦合两个神经元可以同步它们的活动,并影响各种单细胞特性,例如它们的刺激调谐,放电率或增益。所有这些因素都必须考虑,以了解两个神经元应如何耦合,以最佳的处理刺激。我们量化了果蝇(丝光绿蝇)中两个光流处理神经元(Vi和H1)之间相互作用的功能效应。使用生成模型,我们估计了从H1到Vi的单向耦合。特别是在低信噪比(SNR)时,这种耦合极大地改善了Vi中的光流信息。我们确定了限制相互作用强度的两个约束。首先,对于弱耦合,Vi受益于H1的输入,而不伴随其刺激调谐的转变。第二,在低和高SNR下,耦合强度都在单个尖峰所携带的信息最佳的范围内。
Typically, neurons in sensory areas are highly interconnected. Coupling two neurons can synchronize their activity and affect a variety of single-cell properties, such as their stimulus tuning, firing rate or gain. All of these factors must be considered to understand how two neurons should be coupled to optimally process stimuli. We quantified the functional effect of an interaction between two optic-flow processing neurons (Vi and H1) in the fly (Lucilia sericata). Using a generative model, we estimated a uni-directional coupling from H1 to Vi. Especially at a low signal-to-noise ratio (SNR), the coupling strongly improved the information about optic-flow in Vi. We identified two constraints confining the strength of the interaction. First, for weak couplings, Vi benefited from inputs by H1 without a concomitant shift of its stimulus tuning. Second, at both low and high SNR, the coupling strength lay in a range in which the information carried by single spikes is optimal.
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