Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases

Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases
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新型炎症体与 II 型糖尿病、肠道炎症和牛皮癣作为新型炎症体相关疾病

DOI:
10.4172/2157-7412.s3-001
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发表时间:
2013
期刊:
Journal of Genetic Syndromes & Gene Therapy
影响因子:
--
通讯作者:
S. Hofmann
S. Hofmann
中科院分区:
--
文献类型:
--
作者:
M. C. Heymann;S. Hofmann

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炎性小体是代表半胱天冬酶-1的活化平台的多蛋白复合物。这种酶将细胞因子IL-1β、IL-18等加工成其生物活性变体,导致炎症级联反应。导致炎性小体调节缺陷的突变导致严重的自身炎性疾病。   这篇综述提供了一个简短的总结,在自身炎症领域的新见解,包括炎症小体与糖尿病,肠道炎症以及银屑病的关联,并传达了两个新的炎症小体,最近发现的想法。
Inflammasomes are multiprotein complexes representing an activating platform for caspase-1. This enzyme processes the cytokines IL-1β, IL-18 and others into their bioactive variants leading to an inflammatory cascade. Mutations responsible for defects in inflammasome regulation cause severe autoinflammatory disorders.   This review provides a short summary of new insights in the autoinflammatory field including the association of inflammasomes to diabetes, intestinal inflammation as well as psoriasis and communicates the ideas of two novel inflammasomes, recently discovered.
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