Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases
Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases
复制标题
新型炎症体与 II 型糖尿病、肠道炎症和牛皮癣作为新型炎症体相关疾病
DOI:
10.4172/2157-7412.s3-001
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发表时间:
2013
期刊:
影响因子:
--
通讯作者:
S. Hofmann
中科院分区:
文献类型:
--
作者:
M. C. Heymann;S. Hofmann
Inflammasomes are multiprotein complexes representing an activating platform for caspase-1. This enzyme processes the cytokines IL-1β, IL-18 and others into their bioactive variants leading to an inflammatory cascade. Mutations responsible for defects in inflammasome regulation cause severe autoinflammatory disorders.
This review provides a short summary of new insights in the autoinflammatory field including the association of inflammasomes to diabetes, intestinal inflammation as well as psoriasis and communicates the ideas of two novel inflammasomes, recently discovered.
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32.4
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DOI:
10.1073/pnas.84.11.3881
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