Comorbidities and breast cancer survival: a report from the Shanghai Breast Cancer Survival Study.
Comorbidities and breast cancer survival: a report from the Shanghai Breast Cancer Survival Study.
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DOI：
10.1007/s10549-013-2521-2
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发表时间：
2013-05
影响因子：
3.8
通讯作者：
Shu, Xiao Ou
中科院分区：
文献类型：
--
作者：
Nechuta, Sarah;Lu, Wei;Zheng, Ying;Cai, Hui;Bao, Ping-Ping;Gu, Kai;Zheng, Wei;Shu, Xiao Ou
我们利用上海乳腺癌生存研究调查了主要合并症与乳腺癌预后的关系，这是一项基于人群的前瞻性队列研究，研究对象是确诊为乳腺癌的中国女性。分析包括2002-2006年期间，年龄在20-75岁（中位年龄为51岁）的4,664名诊断为I-III期乳腺癌的女性。在诊断后3-11个月对妇女进行访谈（中位数=6.4），并通过面对面访谈和与生命统计登记处的联系进行随访。使用Cox回归模型估计合并症与乳腺癌结局的多变量风险比（hr）和95%置信区间（CIs）。在中位随访5.3年（范围：0.64-8.9年）后，647名妇女死亡（516名死于乳腺癌），632名妇女出现复发/转移。报告的主要合并症包括：高血压（22.4%）、慢性胃炎（14.3%）、糖尿病（6.2%）、慢性支气管炎/哮喘（5.8%）、冠心病（5.0%）和中风（2.2）。糖尿病与总死亡率（调整后的风险比：1.40(1.06-1.85)）和非乳腺癌死亡率（调整后的风险比：2.64(1.63-4.27)）增加相关，但与乳腺癌特异性死亡率（调整后的风险比：0.98(0.68-1.41)）无关，调整了社会人口统计学、临床特征、选择的生活方式因素和其他合并症。有中风史的女性总死亡率（调整后的风险比：1.42(0.91-2.22)）和非乳腺癌死亡率（调整后的风险比：2.52(1.33-4.78)）的风险增加不显著，但乳腺癌特异性死亡率（调整后的风险比：0.78(0.38-1.62)）没有显著增加。总体而言，所有被调查的合并症均与复发无显著相关性。在这个乳腺癌幸存者的大型前瞻性队列中，糖尿病与总死亡率和非乳腺癌死亡率的增加显著相关，卒中史与非乳腺癌死亡率的增加相关。
We investigated the association of major comorbidities with breast cancer outcomes using the Shanghai Breast Cancer Survival Study, a population-based, prospective cohort study of Chinese women diagnosed with breast cancer. Analyses included 4,664 women diagnosed with stage I-III incident breast cancer aged 20–75 years (median age=51) during 2002–2006. Women were interviewed at 3–11 months post-diagnosis (median=6.4) and followed up by in-person interviews and linkage with the vital statistics registry. Multivariable hazard ratios (HRs) and (95% confidence intervals (CIs)) for the associations of comorbidities with breast cancer outcomes were estimated using Cox regression models. After a median follow-up of 5.3 years (range: 0.64–8.9), 647 women died (516 from breast cancer) and 632 recurrence/metastases were documented. The main comorbidities reported included: hypertension (22.4%), chronic gastritis (14.3%), diabetes mellitus (6.2%), chronic bronchitis/asthma (5.8%), coronary heart disease (5.0%), and stroke (2.2). Diabetes was associated with increased risk of total mortality (adjusted HR: 1.40 (1.06–1.85)) and non-breast cancer mortality (adjusted HR: 2.64 (1.63–4.27)), but not breast cancer-specific mortality (adjusted HR: 0.98 (0.68–1.41)), adjusting for socio-demographics, clinical characteristics, selected lifestyle factors, and other comorbidities. Women with a history of stroke had a non-significant increased risk of total mortality (adjusted HR: 1.42 (0.91–2.22)) and a significant increased risk of non-breast cancer mortality (adjusted HR: 2.52 (1.33–4.78)), but not breast cancer-specific mortality (adjusted HR: 0.78 (0.38–1.62)). Overall, none of the comorbidities investigated were significantly associated with recurrence. In this large prospective cohort of breast cancer survivors, diabetes was significantly associated with increased risk of total and non-breast cancer mortality, and history of stroke was associated was associated with increased risk of non-breast cancer mortality.
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影响因子：
45.3
作者：
Barron, Thomas I.;Connolly, Roisin M.;Visvanathan, Kala
通讯作者：
Visvanathan, Kala
影响因子：
8.4
作者：
Louwman, WJ;Janssen-Heijnen, MLG;Coebergh, JWW
通讯作者：
Coebergh, JWW
影响因子：
6.4
作者：
Braithwaite, Dejana;Tammemagi, C. Martin;Esserman, Laura
通讯作者：
Esserman, Laura
DOI：
10.1007/s00432-004-0594-3
发表时间：
2004-11-01
影响因子：
3.6
作者：
Nagel, G;Wedding, U;Katenkamp, D
通讯作者：
Katenkamp, D
影响因子：
6.4
作者：
Dalton, Susanne Oksbjerg;Ross, Lone;Johansen, Christoffer
通讯作者：
Johansen, Christoffer