CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer.
CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer.
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CD8+淋巴细胞/肿瘤出芽指数：代表结直肠癌中肿瘤宿主相互作用的“促/抗肿瘤”方法的独立预后因素。
DOI：
10.1038/sj.bjc.6605318
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发表时间：
2009-10-20
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
结直肠癌侵袭前沿的肿瘤-宿主相互作用，包括上皮-间充质转化及其标志的肿瘤萌芽，是一个重要的预后研究领域。这项研究的目的是确定由适应性免疫微环境(CD8+淋巴细胞)的已建立的亲肿瘤(肿瘤萌发)和宿主相关的‘抗肿瘤’因素定义的‘亲/抗肿瘤’方法对预后的影响。采用组织芯片进行CK22/CD8免疫组织化学双重染色(n=279，队列1)和CD8+免疫组化染色(n=191，队列2)。每高倍视野评价肿瘤芽数、CD8+和CD8+T淋巴细胞 ： 肿瘤芽数指数。在队列1中，低CD8+/ BUDS指数与淋巴结转移(P<；0.001)、血管侵犯(P=0.009)、单因素分析(P<；0.001)和多因素分析(P<；0.001)中的生存不良有关，而且在淋巴结阴性患者中(P=0.002)。在队列2中，CD8+/ BUDS指数与T分期(P<；0.001)、N分期(P=0.041)、血管侵犯(P=0.005)、II期(P=0.019)、III期(P=0.004)、未辅助治疗(P=0.009)和已治疗(P<；0.001)患者的生存相关。CD8+淋巴细胞 ： 肿瘤萌发指数是结直肠癌患者的一个独立预后因素，也是一种很有前途的方法，可以作为该疾病患者未来的预后评分。
The tumour-host interaction at the invasive front of colorectal cancer, including the epithelial–mesenchymal transition and its hallmark ‘tumour budding’, is an important area of investigation in terms of prognosis. The aim of this study was to determine the prognostic impact of a ‘pro-/anti-tumour’ approach defined by an established ‘pro-tumour’ (tumour budding) and host-related ‘anti-tumour’ factor of the adaptive immunological microenvironment (CD8+ lymphocytes). Double immunostaining for CK22/CD8 on whole tissue sections (n=279; Cohort 1) and immunohistochemistry for CD8+ using tissue microarrays (n=191; Cohort 2) was carried out. Tumour buds, CD8+ and CD8+ T-lymphocytes : tumour buds indices were evaluated per high-power field. In Cohort 1, a low-CD8+/ buds index was associated with lymph node metastasis (P<0.001), vascular invasion (P=0.009), worse survival in univariate (P<0.001) and multivariable (P<0.001) analysis, and furthermore in lymph node-negative patients (P=0.002). In Cohort 2, the CD8+/ buds index was associated with T stage (P<0.001), N stage (P=0.041), vascular invasion (P=0.005) and survival in patients with TNM stage II (P=0.019), stage III (P=0.004), and adjuvantly untreated (P=0.009) and treated patients (P<0.001). The CD8+ lymphocyte : tumour-budding index is an independent prognostic factor in colorectal cancer and a promising approach for a future prognostic score for patients with this disease.
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影响因子：
6.4
作者：
Shinto, E;Mochizuki, H;Jass, JR
通讯作者：
Jass, JR
影响因子：
3.9
作者：
HASE, K;SHATNEY, C;VIERRA, M
通讯作者：
VIERRA, M
影响因子：
24.5
作者：
Jass, JR;Do, KA;Leggett, B
通讯作者：
Leggett, B
DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
影响因子：
45.3
作者：
Salama, Paul;Phillips, Michael;Iacopetta, Barry
通讯作者：
Iacopetta, Barry