Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells.
Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells.
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DOI：
10.3892/ol.2014.1936
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发表时间：
2014-05
期刊：
影响因子：
2.9
通讯作者：
Hirano K
中科院分区：
文献类型：
--
作者：
Iguchi K;Hashimoto M;Kubota M;Yamashita S;Nakamura M;Usui S;Sugiyama T;Hirano K
前列腺癌在老年男性中更频繁地发生，并且这样的老年个体通常具有慢性潜在疾病，针对所述慢性潜在疾病施用各种药物以进行治疗。前列腺特异性抗原（PSA）是一种广泛使用的前列腺癌标志物，其水平受到许多药物的影响，例如非甾体抗炎药和他汀类药物。在本研究中，检查了在岐阜药科大学（日本岐阜）药房收集的重复处方上向患者开具的药物对前列腺癌LNCaP细胞中PSA表达水平的影响。在研究的14种药物中，发现糖皮质激素受体激动剂贝特龙增加LNCaP细胞中PSA mRNA表达水平。这种倍他米松诱导的表达是介导的，至少部分是通过雄激素受体（AR）的转录激活。地塞米松，一种典型的糖皮质激素受体激动剂，也被发现刺激AR转录活性，然而，在较低程度上比betastatin。因此，在未来的研究中，检查前列腺癌患者的血清PSA水平是否受beta2的影响将是有趣的。
Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by a number of drugs, such as non-steroidal anti-inflammatory drugs and statins. In the present study, the drugs prescribed to patients on a repeat prescription collected at the pharmacy of the Gifu Pharmaceutical University (Gifu, Japan) were examined for their effects on the levels of PSA expression in prostate cancer LNCaP cells. Among the 14 drugs investigated, betamethasone, an agonist of the glucocorticoid receptor, was found to increase the levels of PSA mRNA expression in the LNCaP cells. This betamethasone-induced expression was mediated, at least in part, through androgen receptor (AR) transcriptional activation. Dexamethasone, a typical agonist of the glucocorticoid receptor, was also found to stimulate the AR transcriptional activity, however, to a lesser extent than betamethasone. Therefore, it would be interesting to examine in future studies whether the serum PSA levels in prostate cancer patients are influenced by betamethasone.
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影响因子：
--
作者：
Otsuka, Takashi;Iguchi, Kazuhiro;Hirano, Kazuyuki
通讯作者：
Hirano, Kazuyuki
DOI：
10.1007/s10552-010-9713-4
发表时间：
2011-03
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Fowke JH;Motley SS;Barocas DA;Cookson MS;Concepcion R;Byerly S;Smith JA Jr
通讯作者：
Smith JA Jr
影响因子：
--
作者：
Iguchi, Kazuhiro;Toyama, Tomoaki;Hirano, Kazuyuki
通讯作者：
Hirano, Kazuyuki
影响因子：
2.9
作者：
Koochekpour, Shahriar
通讯作者：
Koochekpour, Shahriar
影响因子：
4.2
作者：
Iguchi, Kazuhiro;Hayakawa, Yuri;Hirano, Kazuyuki
通讯作者：
Hirano, Kazuyuki