Resolvins suppress tumor growth and enhance cancer therapy.
Resolvins suppress tumor growth and enhance cancer therapy.
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DOI：
10.1084/jem.20170681
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发表时间：
2018-01-02
期刊：
影响因子：
--
通讯作者：
Panigrahy D
中科院分区：
文献类型：
--
作者：
Sulciner ML;Serhan CN;Gilligan MM;Mudge DK;Chang J;Gartung A;Lehner KA;Bielenberg DR;Schmidt B;Dalli J;Greene ER;Gus-Brautbar Y;Piwowarski J;Mammoto T;Zurakowski D;Perretti M;Sukhatme VP;Kaipainen A;Kieran MW;Huang S;Panigrahy D
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Sulciner et al. demonstrate that specific resolvins (RvD1, RvD2, and RvE1) inhibit tumor growth and enhance cancer therapy through the clearance of tumor cell debris. Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy (“tumor cell debris”) stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release after phosphatidylserine exposure. Debris-stimulated tumors were inhibited by antiinflammatory and proresolving lipid autacoids, namely resolvin D1 (RvD1), RvD2, or RvE1. These mediators specifically inhibit debris-stimulated cancer progression by enhancing clearance of debris via macrophage phagocytosis in multiple tumor types. Resolvins counterregulate the release of cytokines/chemokines, including TNFα, IL-6, IL-8, CCL4, and CCL5, by human macrophages stimulated with cell debris. These results demonstrate that enhancing endogenous clearance of tumor cell debris is a new therapeutic target that may complement cytotoxic cancer therapies.
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影响因子：
64.8
作者：
Chiang, Nan;Fredman, Gabrielle;Backhed, Fredrik;Oh, Sungwhan F.;Vickery, Thad;Schmidt, Birgitta A.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1084/jem.20150225
发表时间：
2015-07-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chiang N;Dalli J;Colas RA;Serhan CN
通讯作者：
Serhan CN
表皮黑素细胞的电子显微镜研究和黑色素颗粒的精细结构。
DOI：
10.1083/jcb.8.1.165
发表时间：
1960-09
期刊：
The Journal of biophysical and biochemical cytology
影响因子：
--
作者：
DROCHMANS, P
通讯作者：
DROCHMANS, P
DOI：
10.1084/jem.20050915
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Casares N;Pequignot MO;Tesniere A;Ghiringhelli F;Roux S;Chaput N;Schmitt E;Hamai A;Hervas-Stubbs S;Obeid M;Coutant F;Métivier D;Pichard E;Aucouturier P;Pierron G;Garrido C;Zitvogel L;Kroemer G
通讯作者：
Kroemer G
影响因子：
4.4
作者：
Arita, Makoto;Ohira, Taisuke;Serhan, Charles N.
通讯作者：
Serhan, Charles N.