Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis.
Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis.
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DOI：
10.1007/s00330-021-07988-6
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发表时间：
2021-11
影响因子：
5.9
通讯作者：
Sirlin CB
中科院分区：
文献类型：
--
作者：
Qu Y;Middleton MS;Loomba R;Glaser KJ;Chen J;Hooker JC;Wolfson T;Covarrubias Y;Valasek MA;Fowler KJ;Zhang YN;Sy E;Gamst AC;Wang K;Mamidipalli A;Schwimmer JB;Song B;Reeder SB;Yin M;Ehman RL;Sirlin CB
To investigate associations between histology and hepatic mechanical properties measured using multiparametric magnetic resonance elastography (MRE) in adults with known or suspected nonalcoholic fatty liver disease (NAFLD) without histologic fibrosis. This was a retrospective analysis of 88 adults who underwent 3T MR exams including hepatic MRE and MR imaging to estimate proton density fat fraction (MRI-PDFF) within 180 days of liver biopsy. Associations between MRE mechanical properties (mean shear stiffness (|G*|) by 2D and 3D MRE, and storage modulus (G’), loss modulus (G”), wave attenuation (α), and damping ratio (ζ) by 3D MRE) and histology, demographic and anthropometric data were assessed. In univariate analyses, patients with lobular inflammation grade ≥ 2 had higher 2D |G*| and 3D G″ than those with grade ≤ 1 (P=0.04). |G*| (both 2D and 3D), G′ and G″ increased with age (rho = 0.25 to 0.31; P ≤ 0.03). In multivariable regression analyses, the association between inflammation grade ≥ 2 remained significant for 2D |G*| (P = 0.01) but not for 3D G″ (P = 0.06); age, sex or BMI did not affect the MRE-inflammation relationship (P > 0.20). 2D |G*| and 3D G″ were weakly associated with moderate or severe lobular inflammation in patients with known or suspected NAFLD without fibrosis. With further validation and refinement, these properties might become useful biomarkers of inflammation. Age adjustment may help MRE interpretation, at least in patients with early-stage disease.
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影响因子：
13.5
作者：
Loomba, Rohit;Wolfson, Tanya;Ang, Brandon;Hooker, Jonathan;Behling, Cynthia;Peterson, Michael;Valasek, Mark;Lin, Grace;Brenner, David;Gamst, Anthony;Ehman, Richard;Sirlin, Claude
通讯作者：
Sirlin, Claude
影响因子：
5.7
作者：
Hiscox LV;Schwarb H;McGarry MDJ;Johnson CL
通讯作者：
Johnson CL
DOI：
10.1016/j.cgh.2014.09.046
发表时间：
2015-03
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Singh S;Venkatesh SK;Wang Z;Miller FH;Motosugi U;Low RN;Hassanein T;Asbach P;Godfrey EM;Yin M;Chen J;Keaveny AP;Bridges M;Bohte A;Murad MH;Lomas DJ;Talwalkar JA;Ehman RL
通讯作者：
Ehman RL
DOI：
10.1007/s00464-017-5846-9
发表时间：
2018-04
期刊：
Surgical endoscopy
影响因子：
--
作者：
Luo RB;Suzuki T;Hooker JC;Covarrubias Y;Schlein A;Liu S;Schwimmer JB;Reeder SB;Funk LM;Greenberg JA;Campos GM;Sandler BJ;Horgan S;Sirlin CB;Jacobsen GR
通讯作者：
Jacobsen GR
影响因子：
29.4
作者：
Matteoni, CA;Younossi, ZM;McCullough, AJ
通讯作者：
McCullough, AJ