Aging brain mechanics: Progress and promise of magnetic resonance elastography.
Aging brain mechanics: Progress and promise of magnetic resonance elastography.
复制标题
脑老化力学：磁共振弹性成像的进展与前景。
DOI：
10.1016/j.neuroimage.2021.117889
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发表时间：
2021-05-15
期刊：
影响因子：
5.7
通讯作者：
Johnson CL
中科院分区：
文献类型：
--
作者：
Hiscox LV;Schwarb H;McGarry MDJ;Johnson CL
神经影像学技术可以灵敏地表征健康的大脑老化和检测微妙的神经病理学，具有巨大的潜力，以帮助早期发现神经退行性疾病，如阿尔茨海默氏病。磁共振弹性成像（MRE）最近已经成为一种可靠的、高分辨率的并且特别敏感的技术，其可以非侵入性地表征组织生物力学特性（即，粘弹性）。脑组织的粘弹性提供了一个独特的生物物理特征的神经解剖学，是复杂的组织微结构的组成和组织的代表。在这篇文章中，我们详细介绍了大脑MRE技术的进展如何为健康的大脑衰老，神经退行性变和结构-功能关系提供了独特的见解。我们进一步讨论了其他有前途的技术创新，这些创新将提高脑MRE的特异性和灵敏度，以揭示更多关于脑老化的信息，以及其作为神经退行性疾病的成像生物标志物的潜在价值。MRE敏感性可能特别有助于评估康复策略的疗效，有助于区分痴呆亚型，并了解疾病的因果机制，这可能导致最终的药物开发。
Neuroimaging techniques that can sensitivity characterize healthy brain aging and detect subtle neuropatholo-gies have enormous potential to assist in the early detection of neurodegenerative conditions such as Alzheimer’s disease. Magnetic resonance elastography (MRE) has recently emerged as a reliable, high-resolution, and especially sensitive technique that can noninvasively characterize tissue biomechanical properties (i.e., viscoelasticity) in vivo in the living human brain. Brain tissue viscoelasticity provides a unique biophysical signature of neuroanatomy that are representative of the composition and organization of the complex tissue microstructure. In this article, we detail how progress in brain MRE technology has provided unique insights into healthy brain aging, neurodegeneration, and structure-function relationships. We further discuss additional promising technical innovations that will enhance the specificity and sensitivity for brain MRE to reveal considerably more about brain aging as well as its potentially valuable role as an imaging biomarker of neurodegeneration. MRE sensitivity may be particularly useful for assessing the efficacy of rehabilitation strategies, assisting in differentiating between dementia subtypes, and in understanding the causal mechanisms of disease which may lead to eventual pharmacotherapeutic development.
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影响因子：
3.5
作者：
Daugherty AM;Bender AR;Raz N;Ofen N
通讯作者：
Ofen N
影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
影响因子：
5
作者：
ElSheikh, Mona;Arani, Arvin;Huston, John, III
通讯作者：
Huston, John, III
影响因子：
4.6
作者：
Carey, Daniel;Nolan, Hugh;Meaney, James
通讯作者：
Meaney, James
DOI：
10.1073/pnas.1713308114
发表时间：
2017-11-07
影响因子：
11.1
作者：
Carr, Valerie A.;Bernstein, Jeffrey D.;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.