Molecular genetics of small bowel cancer.
Molecular genetics of small bowel cancer.
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小肠癌的分子遗传学。
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
P. Holt
中科院分区：
文献类型：
--
作者：
N. Arber;A. I. Neugut;I. B. Weinstein;P. Holt
尽管大肠癌变过程中发生的分子遗传变化已得到很好的阐明，但对小肠癌变过程的研究却很少，而小肠癌变过程中这种现象更为罕见。少数研究表明，某些癌基因，即 erbB2、K-ras、细胞周期蛋白 D1 和 p53，都以与大肠癌中的这些现象相似的方式和频率发生改变。一些肿瘤标志物也被发现出现在恶性类癌中。鉴于小肠腺癌和结直肠腺癌的流行病学和腺瘤-癌序列的作用的总体相似性，很可能相同的分子遗传变化发挥了主要作用。需要进一步的工作来证实这一点。如果属实，未来研究的一个潜在重要领域将是确定为什么这些分子遗传变化在小肠中发生的频率远低于大肠。
Although the molecular genetic changes that take place during carcinogenesis in the large bowel have been well elucidated, very little work has been done on the carcinogenesis process in the small bowel where this phenomenon is much rarer. The few studies that have been done to suggest that certain oncogenes, i.e., erbB2, K-ras, cyclin D1, and p53, are all altered in ways and in frequency similar to these phenomena in large bowel cancer. Some tumor markers have been noted to occur in malignant carcinoid tumours as well. Given the overall similarities in the epidemiology and the role of the adenoma-carcinoma sequence for both small bowel adenocarcinoma and colorectal adenocarcinoma, it is highly likely that the same molecular genetic changes play a major role. Further work is needed to confirm this. If true, a potentially important are of future research would be to determine why these molecular genetic changes occur so much less frequently in the small bowel as compared to the large bowel.
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人类胃肠道疾病细胞增殖和分化的生物标志物。
影响因子：
--
作者：
Lipkin,M;Higgins,P
通讯作者：
Higgins,P
DOI：
--
发表时间：
1993
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Neugut,AI;Santos,J
通讯作者：
Santos,J
DOI：
10.1073/pnas.91.19.8969
发表时间：
1994-09-13
影响因子：
11.1
作者：
FODDE, R;EDELMANN, W;KUCHERLAPATI, R
通讯作者：
KUCHERLAPATI, R
影响因子：
4.4
作者：
LUONGO, C;GOULD, KA;MOSER, AR
通讯作者：
MOSER, AR