Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment

Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment
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髓样限制性消融 Shp2 通过放大肿瘤微环境中 CXCL9 和 IFN-γ 产生的相互促进来抑制黑色素瘤生长

DOI:
10.1038/s41388-018-0337-6
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发表时间:
2018-05
期刊:
影响因子:
8
通讯作者:
Ke Yuehai
Ke Yuehai
中科院分区:
医学1区
文献类型:
--
作者:
Xiao Peng;Guo Yuxian;Zhang Huilun;Zhang Xue;Cheng Hongqiang;Cao Qian;Ke Yuehai

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The Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) is generally considered to be an oncogene owing to its ability in enhancing the malignancy of multiple types of tumor cells; however, its role in modulating tumor immunity remains
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