Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network.
Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network.
复制标题
微量元素和维生素补充剂对住院老年患者免疫力和感染的影响：一项随机对照试验。
DOI：
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复制
发表时间：
1999
影响因子：
--
通讯作者：
S. Hercberg
中科院分区：
文献类型：
--
作者：
François Girodon;P. Galan;A. Monget;M. Boutron‐Ruault;P. Brunet‐Lecomte;P. Preziosi;J. Arnaud;J. Manuguerra;S. Hercberg
BACKGROUND
Antioxidant supplementation is thought to improve immunity and thereby reduce infectious morbidity. However, few large trials in elderly people have been conducted that include end points for clinical variables.
OBJECTIVE
To determine the effects of long-term daily supplementation with trace elements (zinc sulfate and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) on immunity and the incidence of infections in institutionalized elderly people.
METHODS
This randomized, double-blind, placebo-controlled intervention study included 725 institutionalized elderly patients (>65 years) from 25 geriatric centers in France. Patients received an oral daily supplement of nutritional doses of trace elements (zinc and selenium sulfide) or vitamins (beta carotene, ascorbic acid, and vitamin E) or a placebo within a 2 x 2 factorial design for 2 years.
MAIN OUTCOME MEASURES
Delayed-type hypersensitivity skin response, humoral response to influenza vaccine, and infectious morbidity and mortality.
RESULTS
Correction of specific nutrient deficiencies was observed after 6 months of supplementation and was maintained for the first year, during which there was no effect of any treatment on delayed-type hypersensitivity skin response. Antibody titers after influenza vaccine were higher in groups that received trace elements alone or associated with vitamins, whereas the vitamin group had significantly lower antibody titers (P<.05). The number of patients without respiratory tract infections during the study was higher in groups that received trace elements (P = .06). Supplementation with neither trace elements nor vitamins significantly reduced the incidence of urogenital infections. Survival analysis for the 2 years did not show any differences between the 4 groups.
CONCLUSIONS
Low-dose supplementation of zinc and selenium provides significant improvement in elderly patients by increasing the humoral response after vaccination and could have considerable public health importance by reducing morbidity from respiratory tract infections.
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老年人群中组合抗氧化剂营养素摄入量对其血浆浓度的影响。
DOI：
10.1093/ajcn/62.6.1228
发表时间：
1995
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Jacques,PF;Halpner,AD;Blumberg,JB
通讯作者：
Blumberg,JB
补充锌和其他微量营养素一年对老年人细胞免疫的影响。
影响因子：
3.5
作者：
Bogden,JD;Oleske,JM;Lavenhar,MA;Munves,EM;Kemp,FW;Bruening,KS;Holding,KJ;Denny,TN;Guarino,MA;Holland,BK
通讯作者：
Holland,BK
对依赖饮食的疗养院居民营养摄入的观察：微量营养素补充剂的利用不足。
影响因子：
3.5
作者：
Rudman,D;Abbasi,AA;Isaacson,K;Karpiuk,E
通讯作者：
Karpiuk,E
影响因子：
158.5
作者：
Omenn, GS;Goodman, GE;Hammar, S
通讯作者：
Hammar, S
DOI：
10.1056/nejm199404143301501
发表时间：
1994-04-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
通讯作者：
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