Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin II in awake Dahl salt-sensitive and -resistant rats
Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin II in awake Dahl salt-sensitive and -resistant rats
复制标题
清醒 Dahl 盐敏感和抗性大鼠中，饮水量存在差异，但肾交感神经活动对中枢盐负荷或血管紧张素 II 的反应没有差异
DOI：
10.1016/s0304-3940(98)00005-6
复制
发表时间：
1998
影响因子：
2.5
通讯作者：
H. Kannan
中科院分区：
文献类型：
--
作者：
Kazuo Kato;M. Saita;Y. Ishizuka;Kiyotaka Nose;T. Kunitake;T. Hanamori;H. Kannan
通过实验研究低盐饮食维持的自由活动达尔盐敏感（DS）和耐盐（DR）大鼠的肾交感神经活动（RSNA）和饮水量对中枢盐负荷或血管紧张素II （A II）的反应是否不同。脑室注射高渗生理盐水（0.3 M, 1 μl/min, 20 min）或A II （100 ng/1 μl）可引起两种菌株的饮水、升压反应和RSNA抑制。与DR大鼠相比，灌注高渗生理盐水或aⅱ后60min内DS大鼠的累积饮水量明显减少。RSNA反应在不同菌株间无显著差异。这些结果表明，清醒DR和DS大鼠的水摄入量不同，而RSNA对急性中枢盐负荷或A II的反应不同。
Experiments were conducted to examine whether renal sympathetic nerve activity (RSNA) and water intake in response to central salt-loading or angiotensin II (A II) differ between freely-moving Dahl salt-sensitive (DS) and -resistant (DR) rats maintained on a low-salt diet. Intracerebroventricular (i.c.v.) administration of hypertonic saline (0.3 M, 1 μl/min, 20 min) or A II (100 ng/1 μl) evoked water intake, pressor response and suppression of RSNA in both strains. The cumulative water intake in DS rats over a 60-min period after i.c.v. infusion of hypertonic saline or A II was significantly attenuated compared with that in DR rats. The RSNA response did not show a significant difference between the strains. These results demonstrate that water intake, but not RSNA response to acute central salt-loading or A II differ between awake DR and DS rats.
清醒 Dahl S 和 R 大鼠的肾功能和钠平衡。
DOI：
10.1152/ajpregu.1987.252.5.r833
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Roman,RJ;Osborn,JL
通讯作者：
Osborn,JL