Renal function and sodium balance in conscious Dahl S and R rats.
Renal function and sodium balance in conscious Dahl S and R rats.
复制标题
清醒 Dahl S 和 R 大鼠的肾功能和钠平衡。
DOI：
10.1152/ajpregu.1987.252.5.r833
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Osborn,JL
中科院分区：
文献类型：
--
作者：
Roman,RJ;Osborn,JL
肾移植研究表明，某种形式的肾功能障碍是达尔盐敏感型(S)大鼠高血压发展的基础。在本研究中，我们比较了清醒的S大鼠和耐盐(R)大鼠的肾脏血流动力学和肾小管功能。与血压正常的Dahl R或高血压Dahl S大鼠相比，高血压前期Dahl S大鼠对静脉等渗氯化钠负荷的利钠反应迟钝。这种差异可能与肾小管处理钠和水的全身性缺陷无关，因为高血压前期的Dahl S大鼠在输注高渗氯化钠溶液时，排出的钠与R或高血压S大鼠相当。DAHL S大鼠在低渗盐水负荷刺激下，与R大鼠相似，也提高了自由水清除率，降低了尿渗透压。高血压前期达尔·S、高血压达尔·S和达尔·R大鼠的肾血流量和肾小球滤过率相似。通过测定8%氯化钠饮食后大鼠钠水平衡、细胞外液容量和血压的变化，进一步探讨钠滞留与高血压发病的可能联系。高盐饮食14d后，Dahl、S和R大鼠的水盐平衡无明显差异。在高盐饮食的第1天，达尔-S大鼠的ECV显著增加了10%，而达尔-R大鼠的ECV无明显变化。
Renal transplantation studies have indicated that some form of renal dysfunction underlies the development of hypertension in Dahl salt-sensitive (S) rats. In the present study, we compared renal hemodynamic and tubular function of conscious Dahl S and salt-resistant (R) rats. Prehypertensive Dahl S rats had a blunted natriuretic response to an intravenous isotonic sodium chloride load compared with the responses of normotensive Dahl R or hypertensive Dahl S rats. This difference was probably not related to a generalized defect in renal tubular handling of sodium and water, since prehypertensive Dahl S rats excreted quantities of sodium comparable to those of R or hypertensive S rats when infused with hypertonic sodium chloride solutions. Dahl S rats also elevated free water clearance and lowered urine osmolality similar to R rats when challenged with a hypotonic saline load. Renal blood flows and glomerular filtration rates were similar in prehypertensive Dahl S, hypertensive Dahl S, and Dahl R rats. The possible link between sodium retention and the development of hypertension in Dahl S rats was examined further by measuring the changes in sodium and water balance, extracellular fluid volume (ECV), and blood pressure after exposure to an 8% sodium chloride diet. No differences could be detected in the salt and water balances of Dahl S and R rats exposed to a high-salt diet for 14 days. ECV increased significantly by 10% in Dahl S rats on the 1st day of a high-salt diet, whereas no change was observed in Dahl R animals.(ABSTRACT TRUNCATED AT 250 WORDS)
登录
查看更多内容
高血压前期和高血压 Dahl 遗传盐敏感大鼠心率异常压力感受反射控制
影响因子：
8.3
作者：
F. Gordon;H. Matsuguchi;A. Mark
通讯作者：
A. Mark
循环功能的整合和控制。
DOI：
--
发表时间：
1976
期刊：
International review of physiology
影响因子：
--
作者：
A. C. Guyton;A. W. Cowley;D. Young;T. Coleman;J. Hall;DeClue Jw
通讯作者：
DeClue Jw
遗传性高血压大鼠对等渗盐水负荷的过度反应。
DOI：
--
发表时间：
1973
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
D. Ben;K. Knudsen;L. Dahl
通讯作者：
L. Dahl
DOI：
--
发表时间：
1986
期刊：
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association
影响因子：
--
作者：
C. F. Chen
通讯作者：
C. F. Chen
可乐定对大鼠的利尿和利尿钠作用。
影响因子：
3.5
作者：
R. Roman;A. W. Cowley;C. Lechene
通讯作者：
C. Lechene